Explore BTK/ATK gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]
| Target ID |
GM-T25005
|
| Target Name |
BTK/ATK
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
695
|
| Gene ID |
100057626 (Equus caballus), 101088062 (Felis catus), 119868479 (Canis lupus familiaris), 12229 (Mus musculus)
367901 (Rattus norvegicus), 533459 (Bos taurus), 695 (Homo sapiens), 703000 (Macaca mulatta)
|
| Target Alternative Names |
AGMX1,AT,ATK,Agammaglobulinemia tyrosine kinase (ATK),B-cell progenitor kinase (BPK),BPK,BTK,Bruton tyrosine kinase,Btk,IGHD3,IMD1,PSCTK1,Tyrosine-protein kinase BTK,XLA,xid
|
| Uniprot Accession |
P35991,Q06187
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
NF-kappa B signaling pathway, Osteoclast differentiation, Platelet activation, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Epstein-Barr virus infection
|
| Gene Ensembl |
ENSECAG00000020984, ENSCAFG00845018798, ENSMUSG00000031264, ENSBTAG00000019250, ENSG00000010671, ENSMMUG00000019573
|
| Target Classification |
Kinase
|
Pre-made viral vector of BTK/ATK cDNA Clones/ORF Plasmid
BTK/ATK siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo695 | Pre-made Human BTK/AT/ATK siRNA oligo Duplex | 695 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo367901 | Pre-made Rat Btk siRNA oligo Duplex | 367901 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12229 | Pre-made Mouse Btk/xid siRNA oligo Duplex | 12229 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo703000 | Pre-made Cynomolgus/Rhesus macaque BTK siRNA oligo Duplex | 703000 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101088062 | Pre-made Cat/Feline BTK siRNA oligo Duplex | 101088062 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo119868479 | Pre-made Dog/Canine BTK siRNA oligo Duplex | 119868479 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo533459 | Pre-made Bovines/Cattle BTK siRNA oligo Duplex | 533459 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100057626 | Pre-made Equine/Horse BTK siRNA oligo Duplex | 100057626 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
BTK/ATK antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T25005-Ab | Human | Anti-Human BTK/ATK monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T25005-Ab | Rat | Anti-Rat BTK/ATK monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T25005-Ab | Mouse | Anti-Mouse BTK/ATK monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T25005-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque BTK/ATK monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T25005-Ab | Cat/Feline | Anti-Cat/Feline BTK/ATK monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T25005-Ab | Dog/Canine | Anti-Dog/Canine BTK/ATK monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T25005-Ab | Bovines/Cattle | Anti-Bovines/Cattle BTK/ATK monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T25005-Ab | Equine/Horse | Anti-Equine/Horse BTK/ATK monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
BTK/ATK VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T25005-Ag | Human | Human BTK/ATK VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T25005-Ag | Rat | Rat BTK/ATK VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T25005-Ag | Mouse | Mouse BTK/ATK VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T25005-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque BTK/ATK VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T25005-Ag | Cat/Feline | Cat/Feline BTK/ATK VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T25005-Ag | Dog/Canine | Dog/Canine BTK/ATK VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T25005-Ag | Bovines/Cattle | Bovines/Cattle BTK/ATK VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T25005-Ag | Equine/Horse | Equine/Horse BTK/ATK VLP (virus-like particle) | HEK293 | Products Developing |
