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Target
sublocation: Introcelluar Protein.
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T23995
|
| Target Name |
PRKCQ
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
5588
|
| Gene ID |
100070207 (Equus caballus), 101100730 (Felis catus), 18761 (Mus musculus), 478013 (Canis lupus familiaris) 505901 (Bos taurus), 5588 (Homo sapiens), 722559 (Macaca mulatta), 85420 (Rattus norvegicus)
|
| Target Alternative Names |
A130035A12Rik,PKC-0,PKC-theta,PKCtheta,PRKCQ,PRKCT,Pkcq,Prkcq,Protein kinase C theta type,nPKC-theta
|
| Uniprot Accession |
Q02111,Q04759,Q9WTQ0
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
NF-kappa B signaling pathway, Vascular smooth muscle contraction, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Inflammatory mediator regulation of TRP channels, Adipocytokine signaling pathway, Insulin resistance, PD-L1 expression and PD-1 checkpoint pathway in cancer
|
| Gene Ensembl |
ENSECAG00000023084, ENSMUSG00000026778, ENSCAFG00845001589, ENSBTAG00000010664, ENSG00000065675, ENSMMUG00000020776
|
| Target Classification |
Kinase
|
PRKCQ siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5588 | Pre-made Human PRKCQ/PRKCT/nPKC-theta siRNA oligo Duplex | 5588 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo85420 | Pre-made Rat Prkcq/Pkcq siRNA oligo Duplex | 85420 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo18761 | Pre-made Mouse Prkcq/Pkcq/PKC-0 siRNA oligo Duplex | 18761 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo722559 | Pre-made Cynomolgus/Rhesus macaque PRKCQ siRNA oligo Duplex | 722559 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101100730 | Pre-made Cat/Feline PRKCQ siRNA oligo Duplex | 101100730 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo478013 | Pre-made Dog/Canine PRKCQ siRNA oligo Duplex | 478013 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo505901 | Pre-made Bovines/Cattle PRKCQ siRNA oligo Duplex | 505901 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100070207 | Pre-made Equine/Horse PRKCQ siRNA oligo Duplex | 100070207 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PRKCQ antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T23995-Ab | Human | Anti-Human PRKCQ monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T23995-Ab | Rat | Anti-Rat PRKCQ monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T23995-Ab | Mouse | Anti-Mouse PRKCQ monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T23995-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PRKCQ monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T23995-Ab | Cat/Feline | Anti-Cat/Feline PRKCQ monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T23995-Ab | Dog/Canine | Anti-Dog/Canine PRKCQ monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T23995-Ab | Bovines/Cattle | Anti-Bovines/Cattle PRKCQ monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T23995-Ab | Equine/Horse | Anti-Equine/Horse PRKCQ monoclonal antibody | mab | Therapeutics Target antibody | Detail |
PRKCQ recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T23995-Ag | Human | Human PRKCQ recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T23995-Ag | Rat | Rat PRKCQ recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T23995-Ag | Mouse | Mouse PRKCQ recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T23995-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PRKCQ recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T23995-Ag | Cat/Feline | Cat/Feline PRKCQ recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T23995-Ag | Dog/Canine | Dog/Canine PRKCQ recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T23995-Ag | Bovines/Cattle | Bovines/Cattle PRKCQ recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T23995-Ag | Equine/Horse | Equine/Horse PRKCQ recombinant protein | Mammalian cell | Detail |