Explore BDKRB2 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. Bradykinin is released upon activation by pathophysiologic conditions such as trauma and inflammation, and binds to its kinin receptors, B1 and B2. The B2 receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. [provided by RefSeq, Apr 2020]
| Target ID |
GM-T23714
|
| Target Name |
BDKRB2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
624
|
| Gene ID |
100054796 (Equus caballus), 12062 (Mus musculus), 25245 (Rattus norvegicus), 403658 (Canis lupus familiaris)
538896 (Bos taurus), 624 (Homo sapiens), 703698 (Macaca mulatta)
|
| Target Alternative Names |
B(2),B2,B2 bradykinin receptor,B2BKR,B2BRA,B2R,BDKRB2,BK-2,BK-2 receptor,BK2,BK2R,BKR2,BRB2,Bdkrb2
|
| Uniprot Accession |
P32299,P25023,P30411
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Calcium signaling pathway, cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, Chagas disease, Pathways in cancer
|
| Gene Ensembl |
ENSMUSG00000021070, ENSCAFG00845003553, ENSBTAG00000021717, ENSG00000168398, ENSMMUG00000043275
|
| Target Classification |
GPCR
|
Pre-made viral vector of BDKRB2 cDNA Clones/ORF Plasmid
BDKRB2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo624 | Pre-made Human BDKRB2/B2R/BK2 siRNA oligo Duplex | 624 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25245 | Pre-made Rat Bdkrb2/B2BKR/B2BRA siRNA oligo Duplex | 25245 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12062 | Pre-made Mouse Bdkrb2/B2/B2R siRNA oligo Duplex | 12062 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo703698 | Pre-made Cynomolgus/Rhesus macaque BDKRB2 siRNA oligo Duplex | 703698 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403658 | Pre-made Dog/Canine BDKRB2 siRNA oligo Duplex | 403658 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo538896 | Pre-made Bovines/Cattle BDKRB2 siRNA oligo Duplex | 538896 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100054796 | Pre-made Equine/Horse BDKRB2 siRNA oligo Duplex | 100054796 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
BDKRB2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T23714-Ab | Human | Anti-Human BDKRB2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T23714-Ab | Rat | Anti-Rat BDKRB2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T23714-Ab | Mouse | Anti-Mouse BDKRB2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T23714-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque BDKRB2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T23714-Ab | Dog/Canine | Anti-Dog/Canine BDKRB2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T23714-Ab | Bovines/Cattle | Anti-Bovines/Cattle BDKRB2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T23714-Ab | Equine/Horse | Anti-Equine/Horse BDKRB2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
BDKRB2 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T23714-Ag | Human | Human BDKRB2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T23714-Ag | Rat | Rat BDKRB2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T23714-Ag | Mouse | Mouse BDKRB2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T23714-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque BDKRB2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T23714-Ag | Dog/Canine | Dog/Canine BDKRB2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T23714-Ag | Bovines/Cattle | Bovines/Cattle BDKRB2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T23714-Ag | Equine/Horse | Equine/Horse BDKRB2 VLP (virus-like particle) | HEK293 | Products Developing |
