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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of this gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Target ID |
GM-T23655
|
Target Name |
WISP3/CCN6
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
8838
|
Gene ID |
100072430 (Equus caballus), 100686448 (Canis lupus familiaris), 100849041 (Bos taurus), 101086230 (Felis catus) 327743 (Mus musculus), 499461 (Rattus norvegicus), 695430 (Macaca mulatta), 8838 (Homo sapiens)
|
Target Alternative Names |
CCN6,Ccn6,WISP3,Gm735,Wisp3,WISP-3,RGD1564120,PPD,LIBC,PPAC,PPRD
|
Uniprot Accession |
D3Z5L9,O95389
|
Uniprot Entry Name |
|
Protein Sub-location |
Secreted Protein/Potential Cytokines
|
Category |
Therapeutics Target, Cytokine Target
|
Disease |
cancer
|
Disease from KEGG |
|
Gene Ensembl |
ENSECAG00000013347, ENSCAFG00845018276, ENSBTAG00000017205, ENSMUSG00000062074, ENSMMUG00000012582, ENSG00000112761
|
Target Classification |
|
Pre-made viral vector of WISP3/CCN6 cDNA Clones/ORF Plasmid
WISP3/CCN6 siRNA/miRNA/oligo for RNA interfence (RNAi)
Cat No. | Product Name | GeneID | Species | Grade | Detail |
---|
pGMoligo8838 | Pre-made Human CCN6/PPD/LIBC siRNA oligo Duplex | 8838 | Human | In-vitro grade; in-vivo grade | Detail |
pGMoligo499461 | Pre-made Rat Ccn6/Wisp3/RGD1564120 siRNA oligo Duplex | 499461 | Rat | In-vitro grade; in-vivo grade | Detail |
pGMoligo327743 | Pre-made Mouse Ccn6/Gm735/Wisp3 siRNA oligo Duplex | 327743 | Mouse | In-vitro grade; in-vivo grade | Detail |
pGMoligo695430 | Pre-made Cynomolgus/Rhesus macaque CCN6/WISP3 siRNA oligo Duplex | 695430 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
pGMoligo101086230 | Pre-made Cat/Feline CCN6/WISP3 siRNA oligo Duplex | 101086230 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
pGMoligo100686448 | Pre-made Dog/Canine CCN6/WISP3 siRNA oligo Duplex | 100686448 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
pGMoligo100849041 | Pre-made Bovines/Cattle CCN6/WISP3 siRNA oligo Duplex | 100849041 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
pGMoligo100072430 | Pre-made Equine/Horse CCN6/WISP3 siRNA oligo Duplex | 100072430 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
WISP3/CCN6 antibody/GMab
Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
---|
GM-Tg-hg-T23655-Ab | Human | Anti-Human WISP3/CCN6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-rg-T23655-Ab | Rat | Anti-Rat WISP3/CCN6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-mg-T23655-Ab | Mouse | Anti-Mouse WISP3/CCN6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-cynog-T23655-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque WISP3/CCN6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-felg-T23655-Ab | Cat/Feline | Anti-Cat/Feline WISP3/CCN6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-cang-T23655-Ab | Dog/Canine | Anti-Dog/Canine WISP3/CCN6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-bovg-T23655-Ab | Bovines/Cattle | Anti-Bovines/Cattle WISP3/CCN6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-equg-T23655-Ab | Equine/Horse | Anti-Equine/Horse WISP3/CCN6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
WISP3/CCN6 recombinant protein
Cat No. | Species | Antigen Name | Expression Platform | Detail |
---|
GM-Tg-hg-T23655-Ag | Human | Human WISP3/CCN6 recombinant protein | Mammalian cell | Detail |
GM-Tg-rg-T23655-Ag | Rat | Rat WISP3/CCN6 recombinant protein | Mammalian cell | Detail |
GM-Tg-mg-T23655-Ag | Mouse | Mouse WISP3/CCN6 recombinant protein | Mammalian cell | Detail |
GM-Tg-cynog-T23655-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque WISP3/CCN6 recombinant protein | Mammalian cell | Detail |
GM-Tg-felg-T23655-Ag | Cat/Feline | Cat/Feline WISP3/CCN6 recombinant protein | Mammalian cell | Detail |
GM-Tg-cang-T23655-Ag | Dog/Canine | Dog/Canine WISP3/CCN6 recombinant protein | Mammalian cell | Detail |
GM-Tg-bovg-T23655-Ag | Bovines/Cattle | Bovines/Cattle WISP3/CCN6 recombinant protein | Mammalian cell | Detail |
GM-Tg-equg-T23655-Ag | Equine/Horse | Equine/Horse WISP3/CCN6 recombinant protein | Mammalian cell | Detail |