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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes N-acetylgalactosamine-6-sulfatase which is a lysosomal exohydrolase required for the degradation of the glycosaminoglycans, keratan sulfate, and chondroitin 6-sulfate. Sequence alterations including point, missense and nonsense mutations, as well as those that affect splicing, result in a deficiency of this enzyme. Deficiencies of this enzyme lead to Morquio A syndrome, a lysosomal storage disorder. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T23292
|
| Target Name |
GALNS
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
2588
|
| Gene ID |
100051284 (Equus caballus), 101099168 (Felis catus), 2588 (Homo sapiens), 292073 (Rattus norvegicus)
489661 (Canis lupus familiaris), 50917 (Mus musculus), 515809 (Bos taurus), 697850 (Macaca mulatta)
|
| Target Alternative Names |
Chondroitinsulfatase (Chondroitinase),GALNAC6S,GALNS,GAS,GalN6S,Galactose-6-sulfate sulfatase (GalN6S),Galns,MPS4A,N-acetylgalactosamine-6-sulfatase,N-acetylgalactosamine-6-sulfate sulfatase (GalNAc6S sulfatase),mFLJ00319
|
| Uniprot Accession |
P34059,Q32KJ6,Q32KH5,Q571E4
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target
|
| Disease |
|
| Disease from KEGG |
Metabolic pathways, Lysosome, Glycosaminoglycan degradation
|
| Gene Ensembl |
ENSECAG00000008732, ENSG00000141012, ENSCAFG00845003078, ENSMUSG00000015027, ENSBTAG00000004568, ENSMMUG00000012430
|
| Target Classification |
|
Pre-made viral vector of GALNS cDNA Clones/ORF Plasmid
GALNS siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo2588 | Pre-made Human GALNS/GAS/MPS4A siRNA oligo Duplex | 2588 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo292073 | Pre-made Rat Galns siRNA oligo Duplex | 292073 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo50917 | Pre-made Mouse Galns/mFLJ00319 siRNA oligo Duplex | 50917 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo697850 | Pre-made Cynomolgus/Rhesus macaque GALNS siRNA oligo Duplex | 697850 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101099168 | Pre-made Cat/Feline GALNS siRNA oligo Duplex | 101099168 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo489661 | Pre-made Dog/Canine GALNS siRNA oligo Duplex | 489661 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo515809 | Pre-made Bovines/Cattle GALNS siRNA oligo Duplex | 515809 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100051284 | Pre-made Equine/Horse GALNS siRNA oligo Duplex | 100051284 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
GALNS antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T23292-Ab | Human | Anti-Human GALNS monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T23292-Ab | Rat | Anti-Rat GALNS monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T23292-Ab | Mouse | Anti-Mouse GALNS monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T23292-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque GALNS monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T23292-Ab | Cat/Feline | Anti-Cat/Feline GALNS monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T23292-Ab | Dog/Canine | Anti-Dog/Canine GALNS monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T23292-Ab | Bovines/Cattle | Anti-Bovines/Cattle GALNS monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T23292-Ab | Equine/Horse | Anti-Equine/Horse GALNS monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GALNS recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T23292-Ag | Human | Human GALNS recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T23292-Ag | Rat | Rat GALNS recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T23292-Ag | Mouse | Mouse GALNS recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T23292-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque GALNS recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T23292-Ag | Cat/Feline | Cat/Feline GALNS recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T23292-Ag | Dog/Canine | Dog/Canine GALNS recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T23292-Ag | Bovines/Cattle | Bovines/Cattle GALNS recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T23292-Ag | Equine/Horse | Equine/Horse GALNS recombinant protein | Mammalian cell | Detail |
