Explore JAK3/JAK-3 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008]
| Target ID |
GM-T23172
|
| Target Name |
JAK3/JAK-3
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3718
|
| Gene ID |
100147451 (Equus caballus), 101092339 (Felis catus), 16453 (Mus musculus), 25326 (Rattus norvegicus)
3718 (Homo sapiens), 538276 (Bos taurus), 610004 (Canis lupus familiaris), 720040 (Macaca mulatta)
|
| Target Alternative Names |
JAK3,Jak3,fae,wil,RATJAK3,JAKL,LJAK,JAK-3,L-JAK,JAK3_HUMAN
|
| Uniprot Accession |
Q62137,Q63272,P52333
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Chemokine signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, JAK-STAT signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Hepatitis B, Measles, Human T-cell leukemia virus 1 infection, Epstein-Barr virus infection, Pathways in cancer, Non-small cell lung cancer
|
| Gene Ensembl |
ENSECAG00000018212, ENSMUSG00000031805, ENSG00000105639, ENSBTAG00000020904, ENSCAFG00845024918
|
| Target Classification |
Kinase, Tumor-associated antigen (TAA)
|
Pre-made viral vector of JAK3/JAK-3 cDNA Clones/ORF Plasmid
JAK3/JAK-3 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3718 | Pre-made Human JAK3/JAKL/LJAK siRNA oligo Duplex | 3718 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25326 | Pre-made Rat Jak3/RATJAK3 siRNA oligo Duplex | 25326 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16453 | Pre-made Mouse Jak3/fae/wil siRNA oligo Duplex | 16453 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo720040 | Pre-made Cynomolgus/Rhesus macaque JAK3 siRNA oligo Duplex | 720040 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101092339 | Pre-made Cat/Feline JAK3 siRNA oligo Duplex | 101092339 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo610004 | Pre-made Dog/Canine JAK3 siRNA oligo Duplex | 610004 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo538276 | Pre-made Bovines/Cattle JAK3 siRNA oligo Duplex | 538276 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100147451 | Pre-made Equine/Horse JAK3 siRNA oligo Duplex | 100147451 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
JAK3/JAK-3 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T23172-Ab | Human | Anti-Human JAK3/JAK-3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T23172-Ab | Rat | Anti-Rat JAK3/JAK-3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T23172-Ab | Mouse | Anti-Mouse JAK3/JAK-3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T23172-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque JAK3/JAK-3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T23172-Ab | Cat/Feline | Anti-Cat/Feline JAK3/JAK-3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T23172-Ab | Dog/Canine | Anti-Dog/Canine JAK3/JAK-3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T23172-Ab | Bovines/Cattle | Anti-Bovines/Cattle JAK3/JAK-3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T23172-Ab | Equine/Horse | Anti-Equine/Horse JAK3/JAK-3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
JAK3/JAK-3 VLP (virus-like particle)
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T23172-Ag | Human | Human JAK3/JAK-3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T23172-Ag | Rat | Rat JAK3/JAK-3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T23172-Ag | Mouse | Mouse JAK3/JAK-3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T23172-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque JAK3/JAK-3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T23172-Ag | Cat/Feline | Cat/Feline JAK3/JAK-3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T23172-Ag | Dog/Canine | Dog/Canine JAK3/JAK-3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T23172-Ag | Bovines/Cattle | Bovines/Cattle JAK3/JAK-3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T23172-Ag | Equine/Horse | Equine/Horse JAK3/JAK-3 VLP (virus-like particle) | HEK293 | Products Developing |
