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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Introcelluar Protein.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T23145
|
| Target Name |
CYP11A1
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
1583
|
| Gene ID |
100034229 (Equus caballus), 101085980 (Felis catus), 13070 (Mus musculus), 1583 (Homo sapiens) 29680 (Rattus norvegicus), 338048 (Bos taurus), 478365 (Canis lupus familiaris), 708065 (Macaca mulatta)
|
| Target Alternative Names |
CYP11A,CYP11A1,CYPXIA1,Cholesterol desmolase,Cholesterol side-chain cleavage enzyme,Cyp11a,Cyp11a1,Cypxia1,Cytochrome P450 11A1,Cytochrome P450(scc),D9Ertd411e,P450(scc),P450SCC,P450scc,Scc,cscc,mitochondrial
|
| Uniprot Accession |
O46515,Q9QZ82,P05108,P14137,P00189
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Metabolic pathways, Steroid hormone biosynthesis, Ovarian steroidogenesis, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, Cushing syndrome
|
| Gene Ensembl |
ENSECAG00000017494, ENSMUSG00000032323, ENSG00000140459, ENSBTAG00000006934, ENSCAFG00845029140, ENSMMUG00000003239
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of CYP11A1 cDNA Clones/ORF Plasmid
CYP11A1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1583 | Pre-made Human CYP11A1/CYP11A/CYPXIA1 siRNA oligo Duplex | 1583 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo29680 | Pre-made Rat Cyp11a1/Cyp11a/Cypxia1 siRNA oligo Duplex | 29680 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo13070 | Pre-made Mouse Cyp11a1/Scc/cscc siRNA oligo Duplex | 13070 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo708065 | Pre-made Cynomolgus/Rhesus macaque CYP11A1 siRNA oligo Duplex | 708065 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101085980 | Pre-made Cat/Feline CYP11A1 siRNA oligo Duplex | 101085980 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo478365 | Pre-made Dog/Canine CYP11A1 siRNA oligo Duplex | 478365 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo338048 | Pre-made Bovines/Cattle CYP11A1/CYP11A/CYPXIA1 siRNA oligo Duplex | 338048 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100034229 | Pre-made Equine/Horse CYP11A1/CYPXIA1/P450SCC siRNA oligo Duplex | 100034229 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CYP11A1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T23145-Ab | Human | Anti-Human CYP11A1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T23145-Ab | Rat | Anti-Rat CYP11A1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T23145-Ab | Mouse | Anti-Mouse CYP11A1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T23145-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CYP11A1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T23145-Ab | Cat/Feline | Anti-Cat/Feline CYP11A1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T23145-Ab | Dog/Canine | Anti-Dog/Canine CYP11A1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T23145-Ab | Bovines/Cattle | Anti-Bovines/Cattle CYP11A1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T23145-Ab | Equine/Horse | Anti-Equine/Horse CYP11A1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
CYP11A1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T23145-Ag | Human | Human CYP11A1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T23145-Ag | Rat | Rat CYP11A1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T23145-Ag | Mouse | Mouse CYP11A1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T23145-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CYP11A1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T23145-Ag | Cat/Feline | Cat/Feline CYP11A1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T23145-Ag | Dog/Canine | Dog/Canine CYP11A1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T23145-Ag | Bovines/Cattle | Bovines/Cattle CYP11A1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T23145-Ag | Equine/Horse | Equine/Horse CYP11A1 recombinant protein | Mammalian cell | Detail |