Explore KCC2/SLC12A5 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Sep 2008]
| Target ID |
GM-T22302
|
| Target Name |
KCC2/SLC12A5
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
57468
|
| Gene ID |
100071141 (Equus caballus), 101085617 (Felis catus), 171373 (Rattus norvegicus), 485905 (Canis lupus familiaris)
510157 (Bos taurus), 57138 (Mus musculus), 57468 (Homo sapiens), 707974 (Macaca mulatta)
|
| Target Alternative Names |
DEE34,EIEE34,EIG14,Electroneutral potassium-chloride cotransporter 2,K-Cl cotransporter 2 (hKCC2),KCC2,Kcc2,Neuronal K-Cl cotransporter,SLC12A5,Slc12a5,Solute carrier family 12 member 5,hKCC2,mKIAA1176
|
| Uniprot Accession |
Q63633,Q91V14,Q9H2X9
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
GABAergic synapse
|
| Gene Ensembl |
ENSECAG00000019126, ENSCAFG00845017857, ENSBTAG00000014179, ENSMUSG00000017740, ENSG00000124140, ENSMMUG00000016553
|
Pre-made viral vector of KCC2/SLC12A5 cDNA Clones/ORF Plasmid
KCC2/SLC12A5 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo57468 | Pre-made Human SLC12A5/KCC2/DEE34 siRNA oligo Duplex | 57468 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo171373 | Pre-made Rat Slc12a5/Kcc2 siRNA oligo Duplex | 171373 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo57138 | Pre-made Mouse Slc12a5/KCC2/mKIAA1176 siRNA oligo Duplex | 57138 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo707974 | Pre-made Cynomolgus/Rhesus macaque SLC12A5 siRNA oligo Duplex | 707974 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101085617 | Pre-made Cat/Feline SLC12A5 siRNA oligo Duplex | 101085617 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo485905 | Pre-made Dog/Canine SLC12A5 siRNA oligo Duplex | 485905 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo510157 | Pre-made Bovines/Cattle SLC12A5 siRNA oligo Duplex | 510157 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100071141 | Pre-made Equine/Horse SLC12A5 siRNA oligo Duplex | 100071141 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
KCC2/SLC12A5 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T22302-Ab | Human | Anti-Human KCC2/SLC12A5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T22302-Ab | Rat | Anti-Rat KCC2/SLC12A5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T22302-Ab | Mouse | Anti-Mouse KCC2/SLC12A5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T22302-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque KCC2/SLC12A5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T22302-Ab | Cat/Feline | Anti-Cat/Feline KCC2/SLC12A5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T22302-Ab | Dog/Canine | Anti-Dog/Canine KCC2/SLC12A5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T22302-Ab | Bovines/Cattle | Anti-Bovines/Cattle KCC2/SLC12A5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T22302-Ab | Equine/Horse | Anti-Equine/Horse KCC2/SLC12A5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
KCC2/SLC12A5 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T22302-Ag | Human | Human KCC2/SLC12A5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T22302-Ag | Rat | Rat KCC2/SLC12A5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T22302-Ag | Mouse | Mouse KCC2/SLC12A5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T22302-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque KCC2/SLC12A5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T22302-Ag | Cat/Feline | Cat/Feline KCC2/SLC12A5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T22302-Ag | Dog/Canine | Dog/Canine KCC2/SLC12A5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T22302-Ag | Bovines/Cattle | Bovines/Cattle KCC2/SLC12A5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T22302-Ag | Equine/Horse | Equine/Horse KCC2/SLC12A5 VLP (virus-like particle) | HEK293 | Products Developing |
