Explore CD46 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]
| Target ID |
GM-T21395
|
| Target Name |
CD46
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
4179
|
| Gene ID |
100057176 (Equus caballus), 17221 (Mus musculus), 29333 (Rattus norvegicus), 4179 (Homo sapiens)
714082 (Macaca mulatta)
|
| Target Alternative Names |
AHUS2,CD46,Cd46,MCP,MIC10,Mcp,Membrane cofactor protein,TLX,TRA2.10,Trophoblast leukocyte common antigen
|
| Uniprot Accession |
O88174,Q9Z0M4,P15529
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease |
cancer
|
| Disease from KEGG |
Complement and coagulation cascades, Measles
|
| Gene Ensembl |
ENSMUSG00000016493, ENSG00000117335, ENSMMUG00000007129
|
| Target Classification |
Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA)
|
Pre-made viral vector of CD46 cDNA Clones/ORF Plasmid
CD46 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo4179 | Pre-made Human CD46/MCP/TLX siRNA oligo Duplex | 4179 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo29333 | Pre-made Rat Cd46/Mcp siRNA oligo Duplex | 29333 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo17221 | Pre-made Mouse Cd46/Mcp siRNA oligo Duplex | 17221 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo714082 | Pre-made Cynomolgus/Rhesus macaque CD46 siRNA oligo Duplex | 714082 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100057176 | Pre-made Equine/Horse CD46 siRNA oligo Duplex | 100057176 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CD46 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T21395-Ab | Human | Anti-Human CD46 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T21395-Ab | Rat | Anti-Rat CD46 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T21395-Ab | Mouse | Anti-Mouse CD46 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T21395-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CD46 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T21395-Ab | Equine/Horse | Anti-Equine/Horse CD46 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
CD46 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T21395-Ag | Human | Human CD46 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T21395-Ag | Rat | Rat CD46 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T21395-Ag | Mouse | Mouse CD46 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T21395-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CD46 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T21395-Ag | Equine/Horse | Equine/Horse CD46 VLP (virus-like particle) | HEK293 | Products Developing |
