Explore CDK5 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
| Target ID |
GM-T20973
|
| Target Name |
CDK5
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
1020
|
| Gene ID |
100063442 (Equus caballus), 101097226 (Felis catus), 1020 (Homo sapiens), 12568 (Mus musculus) 140908 (Rattus norvegicus), 281066 (Bos taurus), 475537 (Canis lupus familiaris), 714445 (Macaca mulatta)
|
| Target Alternative Names |
CDK5,Cdk5,Cell division protein kinase 5,Crk6,Cyclin-dependent kinase 5,Cyclin-dependent-like kinase 5,LIS7,PSSALRE,Serine/threonine-protein kinase PSSALRE,Tau protein kinase II catalytic subunit (TPKII catalytic subunit)
|
| Uniprot Accession |
Q00535,P49615,Q03114,Q02399
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer, Lung Cancer
|
| Disease from KEGG |
Axon guidance, Alzheimer disease, Cocaine addiction
|
| Gene Ensembl |
ENSECAG00000024299, ENSG00000164885, ENSMUSG00000028969, ENSBTAG00000007766, ENSCAFG00845008961, ENSMMUG00000020451
|
| Target Classification |
Kinase
|
Pre-made viral vector of CDK5 cDNA Clones/ORF Plasmid
CDK5 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1020 | Pre-made Human CDK5/LIS7/PSSALRE siRNA oligo Duplex | 1020 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo140908 | Pre-made Rat Cdk5 siRNA oligo Duplex | 140908 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12568 | Pre-made Mouse Cdk5/Crk6 siRNA oligo Duplex | 12568 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo714445 | Pre-made Cynomolgus/Rhesus macaque CDK5 siRNA oligo Duplex | 714445 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101097226 | Pre-made Cat/Feline CDK5 siRNA oligo Duplex | 101097226 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo475537 | Pre-made Dog/Canine CDK5 siRNA oligo Duplex | 475537 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281066 | Pre-made Bovines/Cattle CDK5 siRNA oligo Duplex | 281066 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100063442 | Pre-made Equine/Horse CDK5 siRNA oligo Duplex | 100063442 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CDK5 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T20973-Ab | Human | Anti-Human CDK5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T20973-Ab | Rat | Anti-Rat CDK5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T20973-Ab | Mouse | Anti-Mouse CDK5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T20973-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CDK5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T20973-Ab | Cat/Feline | Anti-Cat/Feline CDK5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T20973-Ab | Dog/Canine | Anti-Dog/Canine CDK5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T20973-Ab | Bovines/Cattle | Anti-Bovines/Cattle CDK5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T20973-Ab | Equine/Horse | Anti-Equine/Horse CDK5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
CDK5 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T20973-Ag | Human | Human CDK5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T20973-Ag | Rat | Rat CDK5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T20973-Ag | Mouse | Mouse CDK5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T20973-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CDK5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T20973-Ag | Cat/Feline | Cat/Feline CDK5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T20973-Ag | Dog/Canine | Dog/Canine CDK5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T20973-Ag | Bovines/Cattle | Bovines/Cattle CDK5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T20973-Ag | Equine/Horse | Equine/Horse CDK5 VLP (virus-like particle) | HEK293 | Products Developing |