Explore STAT6 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
| Target ID |
GM-T20585
|
| Target Name |
STAT6
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
6778
|
| Gene ID |
100050053 (Equus caballus), 100142679 (Canis lupus familiaris), 101089873 (Felis catus), 20852 (Mus musculus) 353105 (Bos taurus), 362896 (Rattus norvegicus), 6778 (Homo sapiens), 714159 (Macaca mulatta)
|
| Target Alternative Names |
D12S1644,HIES6,IL-4 Stat,IL-4-STAT,STAT6,STAT6B,STAT6C,Signal transducer and activator of transcription 6,Stat6
|
| Uniprot Accession |
P52633,P42226
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer, Breast Cancer
|
| Disease from KEGG |
JAK-STAT signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Hepatitis B, Pathways in cancer, Inflammatory bowel disease
|
| Gene Ensembl |
ENSECAG00000008705, ENSCAFG00845009828, ENSMUSG00000002147, ENSBTAG00000006335, ENSG00000166888, ENSMMUG00000017527
|
Pre-made viral vector of STAT6 cDNA Clones/ORF Plasmid
STAT6 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo6778 | Pre-made Human STAT6/HIES6/STAT6B siRNA oligo Duplex | 6778 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo362896 | Pre-made Rat Stat6 siRNA oligo Duplex | 362896 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo20852 | Pre-made Mouse Stat6 siRNA oligo Duplex | 20852 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo714159 | Pre-made Cynomolgus/Rhesus macaque STAT6 siRNA oligo Duplex | 714159 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101089873 | Pre-made Cat/Feline STAT6 siRNA oligo Duplex | 101089873 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100142679 | Pre-made Dog/Canine STAT6 siRNA oligo Duplex | 100142679 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo353105 | Pre-made Bovines/Cattle STAT6 siRNA oligo Duplex | 353105 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100050053 | Pre-made Equine/Horse STAT6 siRNA oligo Duplex | 100050053 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
STAT6 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T20585-Ab | Human | Anti-Human STAT6 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T20585-Ab | Rat | Anti-Rat STAT6 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T20585-Ab | Mouse | Anti-Mouse STAT6 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T20585-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque STAT6 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T20585-Ab | Cat/Feline | Anti-Cat/Feline STAT6 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T20585-Ab | Dog/Canine | Anti-Dog/Canine STAT6 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T20585-Ab | Bovines/Cattle | Anti-Bovines/Cattle STAT6 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T20585-Ab | Equine/Horse | Anti-Equine/Horse STAT6 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
STAT6 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T20585-Ag | Human | Human STAT6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T20585-Ag | Rat | Rat STAT6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T20585-Ag | Mouse | Mouse STAT6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T20585-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque STAT6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T20585-Ag | Cat/Feline | Cat/Feline STAT6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T20585-Ag | Dog/Canine | Dog/Canine STAT6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T20585-Ag | Bovines/Cattle | Bovines/Cattle STAT6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T20585-Ag | Equine/Horse | Equine/Horse STAT6 recombinant protein | Mammalian cell | Detail |