Explore CCR8/CDw198 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Transmembrane Protein.
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T20575
|
| Target Name |
CCR8/CDw198
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
1237
|
| Gene ID |
100055409 (Equus caballus), 101099650 (Felis catus), 1237 (Homo sapiens), 12776 (Mus musculus) 301066 (Rattus norvegicus), 407772 (Bos taurus), 485600 (Canis lupus familiaris), 693806 (Macaca mulatta)
|
| Target Alternative Names |
C-C,C-C CKR-8,C-C chemokine receptor type 8,CC chemokine receptor CHEMR1,CC-CKR-8,CCR-8,CCR8,CDw198,CKR-8,CKRL1,CMKBR8,CMKBRL2,CY6,Ccr8,Chemokine receptor-like 1 (CKR-L1),Cmkbr8,GPR-CY6 (GPRCY6),GPRCY6,TER1,mCCR8
|
| Uniprot Accession |
P51685,P56484,O97665
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Cytokine Target
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, Kaposi sarcoma-associated herpesvirus infection
|
| Gene Ensembl |
ENSECAG00000004303, ENSG00000179934, ENSMUSG00000042262, ENSBTAG00000015483, ENSMMUG00000022962
|
| Target Classification |
GPCR
|
Pre-made viral vector of CCR8/CDw198 cDNA Clones/ORF Plasmid
CCR8/CDw198 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1237 | Pre-made Human CCR8/CY6/TER1 siRNA oligo Duplex | 1237 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo301066 | Pre-made Rat Ccr8 siRNA oligo Duplex | 301066 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12776 | Pre-made Mouse Ccr8/C-C/CCR-8 siRNA oligo Duplex | 12776 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo693806 | Pre-made Cynomolgus/Rhesus macaque CCR8/CCR-8/CC-CKR-8 siRNA oligo Duplex | 693806 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101099650 | Pre-made Cat/Feline CCR8 siRNA oligo Duplex | 101099650 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo485600 | Pre-made Dog/Canine CCR8 siRNA oligo Duplex | 485600 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo407772 | Pre-made Bovines/Cattle CCR8 siRNA oligo Duplex | 407772 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100055409 | Pre-made Equine/Horse CCR8 siRNA oligo Duplex | 100055409 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CCR8/CDw198 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T20575-Ab | Human | Anti-Human CCR8/CDw198 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T20575-Ab | Rat | Anti-Rat CCR8/CDw198 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T20575-Ab | Mouse | Anti-Mouse CCR8/CDw198 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T20575-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CCR8/CDw198 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T20575-Ab | Cat/Feline | Anti-Cat/Feline CCR8/CDw198 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T20575-Ab | Dog/Canine | Anti-Dog/Canine CCR8/CDw198 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T20575-Ab | Bovines/Cattle | Anti-Bovines/Cattle CCR8/CDw198 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T20575-Ab | Equine/Horse | Anti-Equine/Horse CCR8/CDw198 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
CCR8/CDw198 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T20575-Ag | Human | Human CCR8/CDw198 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T20575-Ag | Rat | Rat CCR8/CDw198 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T20575-Ag | Mouse | Mouse CCR8/CDw198 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T20575-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CCR8/CDw198 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T20575-Ag | Cat/Feline | Cat/Feline CCR8/CDw198 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T20575-Ag | Dog/Canine | Dog/Canine CCR8/CDw198 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T20575-Ag | Bovines/Cattle | Bovines/Cattle CCR8/CDw198 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T20575-Ag | Equine/Horse | Equine/Horse CCR8/CDw198 VLP (virus-like particle) | HEK293 | Products Developing |