Explore KCNH2 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene encodes a component of a voltage-activated potassium channel found in cardiac muscle, nerve cells, and microglia. Four copies of this protein interact with one copy of the KCNE2 protein to form a functional potassium channel. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, May 2022]
| Target ID |
GM-T20251
|
| Target Name |
KCNH2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3757
|
| Gene ID |
100064000 (Equus caballus), 101081621 (Felis catus), 117018 (Rattus norvegicus), 16511 (Mus musculus)
3757 (Homo sapiens), 403761 (Canis lupus familiaris), 539971 (Bos taurus), 714174 (Macaca mulatta)
|
| Target Alternative Names |
ERG-1,ERG1,Eag homolog,Eag-related protein 1,Ether-a-go-go-related gene potassium channel 1 (ERG-1,Ether-a-go-go-related protein 1,H-ERG,HERG,HERG1,KCNH2,Kcnh2,Kv11.1,LQT,LQT2,Lqt2,M-erg,Merg1,Potassium voltage-gated channel subfamily H member 2,SQT1,Voltage-gated inwardly rectifying potassium channel KCNH2,Voltage-gated potassium channel subunit Kv11.1,cerg,derg,erg,erg1,hERG-1,hERG1),merg1a,merg1b
|
| Uniprot Accession |
O08962,O35219,Q12809,Q9TSZ3
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
|
| Disease from KEGG |
|
| Gene Ensembl |
ENSECAG00000023797, ENSMUSG00000038319, ENSG00000055118, ENSCAFG00845009911, ENSBTAG00000004078, ENSMMUG00000020436
|
| Target Classification |
Ion Channel
|
Pre-made viral vector of KCNH2 cDNA Clones/ORF Plasmid
KCNH2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3757 | Pre-made Human KCNH2/ERG1/HERG siRNA oligo Duplex | 3757 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo117018 | Pre-made Rat Kcnh2/ERG1 siRNA oligo Duplex | 117018 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16511 | Pre-made Mouse Kcnh2/LQT/ERG1 siRNA oligo Duplex | 16511 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo714174 | Pre-made Cynomolgus/Rhesus macaque KCNH2 siRNA oligo Duplex | 714174 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101081621 | Pre-made Cat/Feline KCNH2 siRNA oligo Duplex | 101081621 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403761 | Pre-made Dog/Canine KCNH2/erg/cerg siRNA oligo Duplex | 403761 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo539971 | Pre-made Bovines/Cattle KCNH2 siRNA oligo Duplex | 539971 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100064000 | Pre-made Equine/Horse KCNH2 siRNA oligo Duplex | 100064000 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
KCNH2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T20251-Ab | Human | Anti-Human KCNH2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T20251-Ab | Rat | Anti-Rat KCNH2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T20251-Ab | Mouse | Anti-Mouse KCNH2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T20251-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque KCNH2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T20251-Ab | Cat/Feline | Anti-Cat/Feline KCNH2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T20251-Ab | Dog/Canine | Anti-Dog/Canine KCNH2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T20251-Ab | Bovines/Cattle | Anti-Bovines/Cattle KCNH2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T20251-Ab | Equine/Horse | Anti-Equine/Horse KCNH2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
KCNH2 VLP (virus-like particle)
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T20251-Ag | Human | Human KCNH2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T20251-Ag | Rat | Rat KCNH2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T20251-Ag | Mouse | Mouse KCNH2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T20251-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque KCNH2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T20251-Ag | Cat/Feline | Cat/Feline KCNH2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T20251-Ag | Dog/Canine | Dog/Canine KCNH2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T20251-Ag | Bovines/Cattle | Bovines/Cattle KCNH2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T20251-Ag | Equine/Horse | Equine/Horse KCNH2 VLP (virus-like particle) | HEK293 | Products Developing |
