Explore LTB gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T20221
|
| Target Name |
LTB
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
4050
|
| Gene ID |
100058364 (Equus caballus), 101085208 (Felis catus), 16994 (Mus musculus), 361795 (Rattus norvegicus)
4050 (Homo sapiens), 481712 (Canis lupus familiaris), 529757 (Bos taurus), 715518 (Macaca mulatta)
|
| Target Alternative Names |
LT-beta,LTB,LTbeta,Ltb,Lymphotoxin-beta,TNFC,TNFSF3,TNLG1C,Tnfc,Tnfsf3,Tnlg1c,Tumor necrosis factor C (TNF-C),Tumor necrosis factor ligand superfamily member 3,p33
|
| Uniprot Accession |
P41155,Q06643,Q5TM22
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Cytokine Target
|
| Disease |
cancer
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Rheumatoid arthritis
|
| Gene Ensembl |
ENSECAG00000051610, ENSMUSG00000024399, ENSG00000227507, ENSCAFG00845010621, ENSMMUG00000008849
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of LTB cDNA Clones/ORF Plasmid
LTB siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo4050 | Pre-made Human LTB/p33/TNFC siRNA oligo Duplex | 4050 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo361795 | Pre-made Rat Ltb siRNA oligo Duplex | 361795 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16994 | Pre-made Mouse Ltb/p33/Tnfc siRNA oligo Duplex | 16994 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo715518 | Pre-made Cynomolgus/Rhesus macaque LTB siRNA oligo Duplex | 715518 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101085208 | Pre-made Cat/Feline LTB siRNA oligo Duplex | 101085208 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo481712 | Pre-made Dog/Canine LTB/TNLG1C siRNA oligo Duplex | 481712 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo529757 | Pre-made Bovines/Cattle LTB siRNA oligo Duplex | 529757 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100058364 | Pre-made Equine/Horse LTB/TNLG1C siRNA oligo Duplex | 100058364 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
LTB antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T20221-Ab | Human | Anti-Human LTB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T20221-Ab | Rat | Anti-Rat LTB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T20221-Ab | Mouse | Anti-Mouse LTB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T20221-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque LTB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T20221-Ab | Cat/Feline | Anti-Cat/Feline LTB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T20221-Ab | Dog/Canine | Anti-Dog/Canine LTB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T20221-Ab | Bovines/Cattle | Anti-Bovines/Cattle LTB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T20221-Ab | Equine/Horse | Anti-Equine/Horse LTB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
LTB VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T20221-Ag | Human | Human LTB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T20221-Ag | Rat | Rat LTB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T20221-Ag | Mouse | Mouse LTB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T20221-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque LTB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T20221-Ag | Cat/Feline | Cat/Feline LTB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T20221-Ag | Dog/Canine | Dog/Canine LTB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T20221-Ag | Bovines/Cattle | Bovines/Cattle LTB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T20221-Ag | Equine/Horse | Equine/Horse LTB VLP (virus-like particle) | HEK293 | Products Developing |
