Explore SLC46A1 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene encodes a transmembrane proton-coupled folate transporter protein that facilitates the movement of folate and antifolate substrates across cell membranes, optimally in acidic pH environments. This protein is also expressed in the brain and choroid plexus where it transports folates into the central nervous system. This protein further functions as a heme transporter in duodenal enterocytes, and potentially in other tissues like liver and kidney. Its localization to the apical membrane or cytoplasm of intestinal cells is modulated by dietary iron levels. Mutations in this gene are associated with autosomal recessive hereditary folate malabsorption disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013]
| Target ID |
GM-T19229
|
| Target Name |
SLC46A1
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
113235
|
| Gene ID |
101100096 (Felis catus), 113235 (Homo sapiens), 303333 (Rattus norvegicus), 491166 (Canis lupus familiaris) 511097 (Bos taurus), 52466 (Mus musculus), 708727 (Macaca mulatta)
|
| Target Alternative Names |
1110002C08Rik,D11Ertd18e,G21,HCP1,Heme carrier protein 1,HsPCFT,PCFT,PCFT/HCP1,Pcft,Proton-coupled folate transporter,RGD1309472,SLC46A1,Slc46a1,Solute carrier family 46 member 1,TRPE,hPCFT,rPCFT
|
| Uniprot Accession |
Q96NT5,Q5EBA8,Q05B81,Q6PEM8
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Antifolate resistance, Vitamin digestion and absorption, Mineral absorption
|
| Gene Ensembl |
ENSG00000076351, ENSCAFG00845007379, ENSBTAG00000002817, ENSMUSG00000020829, ENSMMUG00000019151
|
Pre-made viral vector of SLC46A1 cDNA Clones/ORF Plasmid
SLC46A1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo113235 | Pre-made Human SLC46A1/G21/HCP1 siRNA oligo Duplex | 113235 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo303333 | Pre-made Rat Slc46a1/rPCFT/RGD1309472 siRNA oligo Duplex | 303333 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo52466 | Pre-made Mouse Slc46a1/HCP1/Pcft siRNA oligo Duplex | 52466 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo708727 | Pre-made Cynomolgus/Rhesus macaque SLC46A1 siRNA oligo Duplex | 708727 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101100096 | Pre-made Cat/Feline SLC46A1 siRNA oligo Duplex | 101100096 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo491166 | Pre-made Dog/Canine SLC46A1 siRNA oligo Duplex | 491166 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo511097 | Pre-made Bovines/Cattle SLC46A1/TRPE siRNA oligo Duplex | 511097 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
SLC46A1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T19229-Ab | Human | Anti-Human SLC46A1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T19229-Ab | Rat | Anti-Rat SLC46A1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T19229-Ab | Mouse | Anti-Mouse SLC46A1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T19229-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque SLC46A1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T19229-Ab | Cat/Feline | Anti-Cat/Feline SLC46A1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T19229-Ab | Dog/Canine | Anti-Dog/Canine SLC46A1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T19229-Ab | Bovines/Cattle | Anti-Bovines/Cattle SLC46A1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
SLC46A1 VLP (virus-like particle)
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T19229-Ag | Human | Human SLC46A1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T19229-Ag | Rat | Rat SLC46A1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T19229-Ag | Mouse | Mouse SLC46A1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T19229-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque SLC46A1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T19229-Ag | Cat/Feline | Cat/Feline SLC46A1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T19229-Ag | Dog/Canine | Dog/Canine SLC46A1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T19229-Ag | Bovines/Cattle | Bovines/Cattle SLC46A1 VLP (virus-like particle) | HEK293 | Products Developing |