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Target
sublocation: Transmembrane Protein.
Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Defects in this gene are a cause of familial atrial fibrillation type 7 (ATFB7). [provided by RefSeq, May 2012]
| Target ID |
GM-T17569
|
| Target Name |
KCNA5
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
3741
|
| Gene ID |
100051720 (Equus caballus), 101100573 (Felis catus), 16493 (Mus musculus), 25470 (Rattus norvegicus) 3741 (Homo sapiens), 403995 (Canis lupus familiaris), 508960 (Bos taurus), 711886 (Macaca mulatta)
|
| Target Alternative Names |
ATFB7,HCK1,HK2,HPCN1,KCNA5,KV1.5,Kcna5,Kv1,Kv1.5,PCN1,Potassium voltage-gated channel subfamily A member 5,Voltage-gated potassium channel HK2,Voltage-gated potassium channel subunit Kv1.5
|
| Uniprot Accession |
Q61762,P19024,P22460
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Gene Ensembl |
ENSECAG00000003033, ENSMUSG00000045534, ENSG00000130037, ENSBTAG00000007553, ENSMMUG00000022887
|
| Target Classification |
Ion Channel
|
KCNA5 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3741 | Pre-made Human KCNA5/HK2/HCK1 siRNA oligo Duplex | 3741 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25470 | Pre-made Rat Kcna5/Kv1/Kv1.5 siRNA oligo Duplex | 25470 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16493 | Pre-made Mouse Kcna5/Kv1.5 siRNA oligo Duplex | 16493 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo711886 | Pre-made Cynomolgus/Rhesus macaque KCNA5 siRNA oligo Duplex | 711886 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101100573 | Pre-made Cat/Feline KCNA5 siRNA oligo Duplex | 101100573 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403995 | Pre-made Dog/Canine KCNA5/Kv1.5 siRNA oligo Duplex | 403995 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo508960 | Pre-made Bovines/Cattle KCNA5/Kv1.5 siRNA oligo Duplex | 508960 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100051720 | Pre-made Equine/Horse KCNA5 siRNA oligo Duplex | 100051720 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
KCNA5 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T17569-Ab | Human | Anti-Human KCNA5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T17569-Ab | Rat | Anti-Rat KCNA5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T17569-Ab | Mouse | Anti-Mouse KCNA5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T17569-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque KCNA5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T17569-Ab | Cat/Feline | Anti-Cat/Feline KCNA5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T17569-Ab | Dog/Canine | Anti-Dog/Canine KCNA5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T17569-Ab | Bovines/Cattle | Anti-Bovines/Cattle KCNA5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T17569-Ab | Equine/Horse | Anti-Equine/Horse KCNA5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
KCNA5 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T17569-Ag | Human | Human KCNA5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T17569-Ag | Rat | Rat KCNA5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T17569-Ag | Mouse | Mouse KCNA5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T17569-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque KCNA5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T17569-Ag | Cat/Feline | Cat/Feline KCNA5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T17569-Ag | Dog/Canine | Dog/Canine KCNA5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T17569-Ag | Bovines/Cattle | Bovines/Cattle KCNA5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T17569-Ag | Equine/Horse | Equine/Horse KCNA5 VLP (virus-like particle) | HEK293 | Products Developing |