Explore HNMT gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T17448
|
| Target Name |
HNMT
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
3176
|
| Gene ID |
100051119 (Equus caballus), 101093704 (Felis catus), 140483 (Mus musculus), 3176 (Homo sapiens) 476133 (Canis lupus familiaris), 613413 (Bos taurus), 81676 (Rattus norvegicus)
|
| Target Alternative Names |
1500031F01Rik,HMT,HNMT,HNMT-S1,HNMT-S2,Histamine N-methyltransferase,Hnmt,MRT51
|
| Uniprot Accession |
Q91VF2,P50135,Q58DV7,Q01984
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Metabolic pathways
|
| Gene Ensembl |
ENSECAG00000011592, ENSMUSG00000026986, ENSG00000150540, ENSCAFG00845010412, ENSBTAG00000014432
|
Pre-made viral vector of HNMT cDNA Clones/ORF Plasmid
HNMT siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3176 | Pre-made Human HNMT/HMT/MRT51 siRNA oligo Duplex | 3176 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo81676 | Pre-made Rat Hnmt siRNA oligo Duplex | 81676 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo140483 | Pre-made Mouse Hnmt/1500031F01Rik siRNA oligo Duplex | 140483 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101093704 | Pre-made Cat/Feline HNMT siRNA oligo Duplex | 101093704 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo476133 | Pre-made Dog/Canine HNMT siRNA oligo Duplex | 476133 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo613413 | Pre-made Bovines/Cattle HNMT siRNA oligo Duplex | 613413 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100051119 | Pre-made Equine/Horse HNMT siRNA oligo Duplex | 100051119 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
HNMT antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T17448-Ab | Human | Anti-Human HNMT monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T17448-Ab | Rat | Anti-Rat HNMT monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T17448-Ab | Mouse | Anti-Mouse HNMT monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T17448-Ab | Cat/Feline | Anti-Cat/Feline HNMT monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T17448-Ab | Dog/Canine | Anti-Dog/Canine HNMT monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T17448-Ab | Bovines/Cattle | Anti-Bovines/Cattle HNMT monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T17448-Ab | Equine/Horse | Anti-Equine/Horse HNMT monoclonal antibody | mab | Therapeutics Target antibody | Detail |
HNMT recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T17448-Ag | Human | Human HNMT recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T17448-Ag | Rat | Rat HNMT recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T17448-Ag | Mouse | Mouse HNMT recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T17448-Ag | Cat/Feline | Cat/Feline HNMT recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T17448-Ag | Dog/Canine | Dog/Canine HNMT recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T17448-Ag | Bovines/Cattle | Bovines/Cattle HNMT recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T17448-Ag | Equine/Horse | Equine/Horse HNMT recombinant protein | Mammalian cell | Detail |