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Target
sublocation: Secreted Protein/Potential Cytokines.
This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014]
| Target ID |
GM-T16888
|
| Target Name |
CCL11/Eotaxin
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
6356
|
| Gene ID |
574218 (Macaca mulatta), 6356 (Homo sapiens)
|
| Target Alternative Names |
C-C motif chemokine 11,CCL11,Eosinophil chemotactic protein,Eotaxin,SCYA11,Small-inducible cytokine A11
|
| Uniprot Accession |
Q8MIT7,P51671
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target, INN Index, Cytokine Target
|
| Disease |
Ovary Cancer
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, IL-17 signaling pathway, Asthma
|
| Gene Ensembl |
ENSMMUG00000064793, ENSG00000172156
|
Pre-made viral vector of CCL11/Eotaxin cDNA Clones/ORF Plasmid
CCL11/Eotaxin siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo6356 | Pre-made Human CCL11/SCYA11 siRNA oligo Duplex | 6356 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo574218 | Pre-made Cynomolgus/Rhesus macaque CCL11/SCYA11/Eotaxin siRNA oligo Duplex | 574218 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
CCL11/Eotaxin antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T16888-Ab | Human | Anti-Human CCL11/Eotaxin monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T16888-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CCL11/Eotaxin monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
CCL11/Eotaxin recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T16888-Ag | Human | Human CCL11/Eotaxin recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T16888-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CCL11/Eotaxin recombinant protein | Mammalian cell | Detail |