Explore nNOS/NOS1 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011]
| Target ID |
GM-T16117
|
| Target Name |
nNOS/NOS1
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
4842
|
| Gene ID |
100051079 (Equus caballus), 101100342 (Felis catus), 18125 (Mus musculus), 24598 (Rattus norvegicus) 477498 (Canis lupus familiaris), 4842 (Homo sapiens), 536132 (Bos taurus), 693781 (Macaca mulatta)
|
| Target Alternative Names |
2310005C01Rik,Constitutive NOS,IHPS1,N-NOS,NC-NOS,NO,NOS,NOS type I,NOS-I,NOS1,Neuronal NOS (N-NOS,Nitric oxide synthase,Nitric oxide synthase 1,Nos-1,Nos1,Peptidyl-cysteine S-nitrosylase NOS1,bNOS,brain (bNOS),nNOS,nNOS)
|
| Uniprot Accession |
Q9Z0J4,P29476,P29475
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
Breast Cancer
|
| Disease from KEGG |
Metabolic pathways, Calcium signaling pathway, Phagosome, Circadian entrainment, Relaxin signaling pathway, Salivary secretion, Alzheimer disease
|
| Gene Ensembl |
ENSECAG00000009126, ENSMUSG00000029361, ENSCAFG00845026722, ENSG00000089250, ENSBTAG00000002023, ENSMMUG00000014027
|
nNOS/NOS1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo4842 | Pre-made Human NOS1/NOS/bNOS siRNA oligo Duplex | 4842 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24598 | Pre-made Rat Nos1/bNOS siRNA oligo Duplex | 24598 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo18125 | Pre-made Mouse Nos1/NO/NOS siRNA oligo Duplex | 18125 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo693781 | Pre-made Cynomolgus/Rhesus macaque NOS1 siRNA oligo Duplex | 693781 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101100342 | Pre-made Cat/Feline NOS1 siRNA oligo Duplex | 101100342 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo477498 | Pre-made Dog/Canine NOS1 siRNA oligo Duplex | 477498 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo536132 | Pre-made Bovines/Cattle NOS1 siRNA oligo Duplex | 536132 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100051079 | Pre-made Equine/Horse NOS1 siRNA oligo Duplex | 100051079 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
nNOS/NOS1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T16117-Ab | Human | Anti-Human nNOS/NOS1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T16117-Ab | Rat | Anti-Rat nNOS/NOS1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T16117-Ab | Mouse | Anti-Mouse nNOS/NOS1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T16117-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque nNOS/NOS1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T16117-Ab | Cat/Feline | Anti-Cat/Feline nNOS/NOS1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T16117-Ab | Dog/Canine | Anti-Dog/Canine nNOS/NOS1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T16117-Ab | Bovines/Cattle | Anti-Bovines/Cattle nNOS/NOS1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T16117-Ab | Equine/Horse | Anti-Equine/Horse nNOS/NOS1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
nNOS/NOS1 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T16117-Ag | Human | Human nNOS/NOS1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T16117-Ag | Rat | Rat nNOS/NOS1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T16117-Ag | Mouse | Mouse nNOS/NOS1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T16117-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque nNOS/NOS1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T16117-Ag | Cat/Feline | Cat/Feline nNOS/NOS1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T16117-Ag | Dog/Canine | Dog/Canine nNOS/NOS1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T16117-Ag | Bovines/Cattle | Bovines/Cattle nNOS/NOS1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T16117-Ag | Equine/Horse | Equine/Horse nNOS/NOS1 VLP (virus-like particle) | HEK293 | Products Developing |