Explore CTLA-4/CD152/CTLA4 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T15000
|
| Target Name |
CTLA-4/CD152/CTLA4
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
1493
|
| Gene ID |
100067931 (Equus caballus), 12477 (Mus musculus), 1493 (Homo sapiens), 281732 (Bos taurus)
403696 (Canis lupus familiaris), 493743 (Felis catus), 63835 (Rattus norvegicus), 705673 (Macaca mulatta)
|
| Target Alternative Names |
ALPS5,CD,CD152,CELIAC3,CTLA-4,CTLA4,Cd152,Ctla-4,Ctla4,Cytotoxic T-lymphocyte protein 4,Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4),GRD4,GSE,IDDM12,Ly-56,sCTLA4
|
| Uniprot Accession |
P09793,P16410,Q9XSI1
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target, INN Index
|
| Disease |
cancer, Hepatitis - type 1 autoimmune, Grave's Disease, Autoimmune thyroid diseases, asthma
|
| Disease from KEGG |
Cell adhesion molecules, T cell receptor signaling pathway, Autoimmune thyroid disease, Rheumatoid arthritis
|
| Gene Ensembl |
ENSECAG00000003996, ENSMUSG00000026011, ENSG00000163599, ENSBTAG00000013170, ENSCAFG00845018252, ENSMMUG00000015903
|
| Target Classification |
Checkpoint-Immuno Oncology
|
Pre-made viral vector of CTLA-4/CD152/CTLA4 cDNA Clones/ORF Plasmid
CTLA-4/CD152/CTLA4 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1493 | Pre-made Human CTLA4/CD/GSE siRNA oligo Duplex | 1493 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo63835 | Pre-made Rat Ctla4/Cd152/CTLA-4 siRNA oligo Duplex | 63835 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12477 | Pre-made Mouse Ctla4/Cd152/Ly-56 siRNA oligo Duplex | 12477 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo705673 | Pre-made Cynomolgus/Rhesus macaque CTLA4/CTLA-4 siRNA oligo Duplex | 705673 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo493743 | Pre-made Cat/Feline CTLA4/CD152 siRNA oligo Duplex | 493743 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403696 | Pre-made Dog/Canine CTLA4/CD152 siRNA oligo Duplex | 403696 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281732 | Pre-made Bovines/Cattle CTLA4/CD152/CTLA-4 siRNA oligo Duplex | 281732 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100067931 | Pre-made Equine/Horse CTLA4 siRNA oligo Duplex | 100067931 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CTLA-4/CD152/CTLA4 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T15000-Ab | Human | Anti-Human CTLA-4/CD152/CTLA4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T15000-Ab | Rat | Anti-Rat CTLA-4/CD152/CTLA4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T15000-Ab | Mouse | Anti-Mouse CTLA-4/CD152/CTLA4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T15000-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CTLA-4/CD152/CTLA4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T15000-Ab | Cat/Feline | Anti-Cat/Feline CTLA-4/CD152/CTLA4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T15000-Ab | Dog/Canine | Anti-Dog/Canine CTLA-4/CD152/CTLA4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T15000-Ab | Bovines/Cattle | Anti-Bovines/Cattle CTLA-4/CD152/CTLA4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T15000-Ab | Equine/Horse | Anti-Equine/Horse CTLA-4/CD152/CTLA4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
CTLA-4/CD152/CTLA4 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T15000-Ag | Human | Human CTLA-4/CD152/CTLA4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T15000-Ag | Rat | Rat CTLA-4/CD152/CTLA4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T15000-Ag | Mouse | Mouse CTLA-4/CD152/CTLA4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T15000-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CTLA-4/CD152/CTLA4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T15000-Ag | Cat/Feline | Cat/Feline CTLA-4/CD152/CTLA4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T15000-Ag | Dog/Canine | Dog/Canine CTLA-4/CD152/CTLA4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T15000-Ag | Bovines/Cattle | Bovines/Cattle CTLA-4/CD152/CTLA4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T15000-Ag | Equine/Horse | Equine/Horse CTLA-4/CD152/CTLA4 VLP (virus-like particle) | HEK293 | Products Developing |
