Explore LGR5 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
| Target ID |
GM-T14231
|
| Target Name |
LGR5
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
8549
|
| Gene ID |
100064565 (Equus caballus), 101080720 (Felis catus), 14160 (Mus musculus), 299802 (Rattus norvegicus)
520189 (Bos taurus), 609478 (Canis lupus familiaris), 718661 (Macaca mulatta), 8549 (Homo sapiens)
|
| Target Alternative Names |
FEX,G-protein coupled receptor 49,G-protein coupled receptor 67,G-protein coupled receptor HG38,GPR49,GPR67,GRP49,Gpr49,HG38,LGR5,Leucine-rich repeat-containing G-protein coupled receptor 5,Lgr5
|
| Uniprot Accession |
Q9Z1P4,D4AC13,F1MT22,O75473
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, INN Index
|
| Disease |
cancer
|
| Disease from KEGG |
Wnt signaling pathway
|
| Gene Ensembl |
ENSECAG00000011949, ENSMUSG00000020140, ENSBTAG00000013256, ENSCAFG00845022363, ENSMMUG00000020942, ENSG00000139292
|
| Target Classification |
GPCR, Tumor-associated antigen (TAA)
|
Pre-made viral vector of LGR5 cDNA Clones/ORF Plasmid
LGR5 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo8549 | Pre-made Human LGR5/FEX/HG38 siRNA oligo Duplex | 8549 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo299802 | Pre-made Rat Lgr5/Gpr49 siRNA oligo Duplex | 299802 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo14160 | Pre-made Mouse Lgr5/FEX/Gpr49 siRNA oligo Duplex | 14160 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo718661 | Pre-made Cynomolgus/Rhesus macaque LGR5 siRNA oligo Duplex | 718661 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101080720 | Pre-made Cat/Feline LGR5 siRNA oligo Duplex | 101080720 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo609478 | Pre-made Dog/Canine LGR5 siRNA oligo Duplex | 609478 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo520189 | Pre-made Bovines/Cattle LGR5 siRNA oligo Duplex | 520189 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100064565 | Pre-made Equine/Horse LGR5 siRNA oligo Duplex | 100064565 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
LGR5 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T14231-Ab | Human | Anti-Human LGR5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T14231-Ab | Rat | Anti-Rat LGR5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T14231-Ab | Mouse | Anti-Mouse LGR5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T14231-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque LGR5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T14231-Ab | Cat/Feline | Anti-Cat/Feline LGR5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T14231-Ab | Dog/Canine | Anti-Dog/Canine LGR5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T14231-Ab | Bovines/Cattle | Anti-Bovines/Cattle LGR5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T14231-Ab | Equine/Horse | Anti-Equine/Horse LGR5 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
LGR5 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T14231-Ag | Human | Human LGR5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T14231-Ag | Rat | Rat LGR5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T14231-Ag | Mouse | Mouse LGR5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T14231-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque LGR5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T14231-Ag | Cat/Feline | Cat/Feline LGR5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T14231-Ag | Dog/Canine | Dog/Canine LGR5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T14231-Ag | Bovines/Cattle | Bovines/Cattle LGR5 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T14231-Ag | Equine/Horse | Equine/Horse LGR5 VLP (virus-like particle) | HEK293 | Products Developing |
