Explore Integrin Beta 7/ITGB7 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Transmembrane Protein.
This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]
| Target ID |
GM-T14065
|
| Target Name |
Integrin Beta 7/ITGB7
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
3695
|
| Gene ID |
100063747 (Equus caballus), 101099982 (Felis catus), 16421 (Mus musculus), 25713 (Rattus norvegicus) 3695 (Homo sapiens), 477598 (Canis lupus familiaris), 514031 (Bos taurus), 699405 (Macaca mulatta)
|
| Target Alternative Names |
Gut homing receptor beta subunit,ITGB7,Integrin Beta 7,Integrin beta-7,Itgb7,Ly69
|
| Uniprot Accession |
P26011,P26010
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target, INN Index
|
| Disease from KEGG |
PI3K-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, Cell adhesion molecules, Intestinal immune network for IgA production, Regulation of actin cytoskeleton, Human papillomavirus infection, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy
|
| Gene Ensembl |
ENSECAG00000013502, ENSMUSG00000001281, ENSG00000139626, ENSCAFG00845021413, ENSBTAG00000018993, ENSMMUG00000005245
|
| Target Classification |
Checkpoint-Immuno Oncology
|
Pre-made viral vector of Integrin Beta 7/ITGB7 cDNA Clones/ORF Plasmid
Integrin Beta 7/ITGB7 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3695 | Pre-made Human ITGB7 siRNA oligo Duplex | 3695 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25713 | Pre-made Rat Itgb7 siRNA oligo Duplex | 25713 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16421 | Pre-made Mouse Itgb7/Ly69 siRNA oligo Duplex | 16421 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo699405 | Pre-made Cynomolgus/Rhesus macaque ITGB7 siRNA oligo Duplex | 699405 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101099982 | Pre-made Cat/Feline ITGB7 siRNA oligo Duplex | 101099982 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo477598 | Pre-made Dog/Canine ITGB7 siRNA oligo Duplex | 477598 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo514031 | Pre-made Bovines/Cattle ITGB7 siRNA oligo Duplex | 514031 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100063747 | Pre-made Equine/Horse ITGB7 siRNA oligo Duplex | 100063747 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
Integrin Beta 7/ITGB7 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T14065-Ab | Human | Anti-Human Integrin Beta 7/ITGB7 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T14065-Ab | Rat | Anti-Rat Integrin Beta 7/ITGB7 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T14065-Ab | Mouse | Anti-Mouse Integrin Beta 7/ITGB7 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T14065-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque Integrin Beta 7/ITGB7 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T14065-Ab | Cat/Feline | Anti-Cat/Feline Integrin Beta 7/ITGB7 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T14065-Ab | Dog/Canine | Anti-Dog/Canine Integrin Beta 7/ITGB7 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T14065-Ab | Bovines/Cattle | Anti-Bovines/Cattle Integrin Beta 7/ITGB7 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T14065-Ab | Equine/Horse | Anti-Equine/Horse Integrin Beta 7/ITGB7 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
Integrin Beta 7/ITGB7 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T14065-Ag | Human | Human Integrin Beta 7/ITGB7 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T14065-Ag | Rat | Rat Integrin Beta 7/ITGB7 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T14065-Ag | Mouse | Mouse Integrin Beta 7/ITGB7 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T14065-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque Integrin Beta 7/ITGB7 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T14065-Ag | Cat/Feline | Cat/Feline Integrin Beta 7/ITGB7 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T14065-Ag | Dog/Canine | Dog/Canine Integrin Beta 7/ITGB7 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T14065-Ag | Bovines/Cattle | Bovines/Cattle Integrin Beta 7/ITGB7 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T14065-Ag | Equine/Horse | Equine/Horse Integrin Beta 7/ITGB7 VLP (virus-like particle) | HEK293 | Products Developing |