Explore Hsc70/HSPA8 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
| Target ID |
GM-T12817
|
| Target Name |
Hsc70/HSPA8
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3312
|
| Gene ID |
100009679 (Equus caballus), 101087422 (Felis catus), 15481 (Mus musculus), 24468 (Rattus norvegicus)
281831 (Bos taurus), 3312 (Homo sapiens), 479406 (Canis lupus familiaris), 707989 (Macaca mulatta)
|
| Target Alternative Names |
2410008N15Rik,HEL-33,HEL-S-72p,HSC54,HSC70,HSC71,HSP71,HSP73,HSPA10,HSPA8,Heat shock 70 kDa protein 8,Heat shock cognate 71 kDa protein,Heat shock protein family A member 8,Hsc70,Hsc71,Hsc73,Hsp73,Hspa10,Hspa8,LAP-1,LAP1,LPS-associated protein 1),Lipopolysaccharide-associated protein 1 (LAP-1,NIP71
|
| Uniprot Accession |
A2Q0Z1,P63017,P63018,P19120,P11142
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer, Dent disease
|
| Disease from KEGG |
MAPK signaling pathway, Protein processing in endoplasmic reticulum, Longevity regulating pathway - multiple species, Antigen processing and presentation, Legionellosis, Toxoplasmosis, Measles, Lipid and atherosclerosis
|
| Gene Ensembl |
ENSECAG00000013510,ENSECAG00000037704, ENSMUSG00000015656, ENSBTAG00000013162, ENSG00000109971, ENSCAFG00845012887, ENSMMUG00000004696
|
Pre-made viral vector of Hsc70/HSPA8 cDNA Clones/ORF Plasmid
Hsc70/HSPA8 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3312 | Pre-made Human HSPA8/LAP1/HSC54 siRNA oligo Duplex | 3312 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24468 | Pre-made Rat Hspa8/Hsc70 siRNA oligo Duplex | 24468 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo15481 | Pre-made Mouse Hspa8/Hsc70/Hsc71 siRNA oligo Duplex | 15481 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo707989 | Pre-made Cynomolgus/Rhesus macaque HSPA8 siRNA oligo Duplex | 707989 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101087422 | Pre-made Cat/Feline HSPA8 siRNA oligo Duplex | 101087422 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo479406 | Pre-made Dog/Canine HSPA8 siRNA oligo Duplex | 479406 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281831 | Pre-made Bovines/Cattle HSPA8/Hsc70/HSPA10 siRNA oligo Duplex | 281831 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100009679 | Pre-made Equine/Horse HSPA8 siRNA oligo Duplex | 100009679 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
Hsc70/HSPA8 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T12817-Ab | Human | Anti-Human Hsc70/HSPA8 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T12817-Ab | Rat | Anti-Rat Hsc70/HSPA8 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T12817-Ab | Mouse | Anti-Mouse Hsc70/HSPA8 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T12817-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque Hsc70/HSPA8 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T12817-Ab | Cat/Feline | Anti-Cat/Feline Hsc70/HSPA8 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T12817-Ab | Dog/Canine | Anti-Dog/Canine Hsc70/HSPA8 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T12817-Ab | Bovines/Cattle | Anti-Bovines/Cattle Hsc70/HSPA8 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T12817-Ab | Equine/Horse | Anti-Equine/Horse Hsc70/HSPA8 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
Hsc70/HSPA8 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T12817-Ag | Human | Human Hsc70/HSPA8 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T12817-Ag | Rat | Rat Hsc70/HSPA8 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T12817-Ag | Mouse | Mouse Hsc70/HSPA8 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T12817-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque Hsc70/HSPA8 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T12817-Ag | Cat/Feline | Cat/Feline Hsc70/HSPA8 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T12817-Ag | Dog/Canine | Dog/Canine Hsc70/HSPA8 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T12817-Ag | Bovines/Cattle | Bovines/Cattle Hsc70/HSPA8 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T12817-Ag | Equine/Horse | Equine/Horse Hsc70/HSPA8 VLP (virus-like particle) | HEK293 | Products Developing |
