Explore GNRHR gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene. [provided by RefSeq, Jul 2008]
Target ID |
GM-T12475
|
Target Name |
GNRHR
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
2798
|
Gene ID |
100033874 (Equus caballus), 101088838 (Felis catus), 14715 (Mus musculus), 2798 (Homo sapiens) 281798 (Bos taurus), 403718 (Canis lupus familiaris), 711577 (Macaca mulatta), 81668 (Rattus norvegicus)
|
Target Alternative Names |
GNRHR,Gnrhr,HH7,GRHR,LRHR,LHRHR,GNRHR1,GnRH-R,GH1,Lhrhr
|
Uniprot Accession |
O18821,Q01776,P30968,P32236,Q9MZI6,Q8SPZ1,P30969
|
Uniprot Entry Name |
|
Protein Sub-location |
Transmembrane Protein
|
Category |
Therapeutics Target, Immuno-oncology Target
|
Disease |
cancer
|
Disease from KEGG |
Neuroactive ligand-receptor interaction, GnRH signaling pathway
|
Gene Ensembl |
ENSECAG00000005763, ENSMUSG00000029255, ENSG00000109163, ENSBTAG00000000438, ENSCAFG00845008435, ENSMMUG00000003779
|
Target Classification |
GPCR, Checkpoint-Immuno Oncology
|
Pre-made viral vector of GNRHR cDNA Clones/ORF Plasmid
GNRHR siRNA/miRNA/oligo for RNA interfence (RNAi)
Cat No. | Product Name | GeneID | Species | Grade | Detail |
---|
pGMoligo2798 | Pre-made Human GNRHR/HH7/GRHR siRNA oligo Duplex | 2798 | Human | In-vitro grade; in-vivo grade | Detail |
pGMoligo81668 | Pre-made Rat Gnrhr/GH1/Lhrhr siRNA oligo Duplex | 81668 | Rat | In-vitro grade; in-vivo grade | Detail |
pGMoligo14715 | Pre-made Mouse Gnrhr siRNA oligo Duplex | 14715 | Mouse | In-vitro grade; in-vivo grade | Detail |
pGMoligo711577 | Pre-made Cynomolgus/Rhesus macaque GNRHR/GnRH-R siRNA oligo Duplex | 711577 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
pGMoligo101088838 | Pre-made Cat/Feline GNRHR siRNA oligo Duplex | 101088838 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
pGMoligo403718 | Pre-made Dog/Canine GNRHR siRNA oligo Duplex | 403718 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
pGMoligo281798 | Pre-made Bovines/Cattle GNRHR siRNA oligo Duplex | 281798 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
pGMoligo100033874 | Pre-made Equine/Horse GNRHR siRNA oligo Duplex | 100033874 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
GNRHR antibody/GMab
Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
---|
GM-Tg-hg-T12475-Ab | Human | Anti-Human GNRHR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-rg-T12475-Ab | Rat | Anti-Rat GNRHR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-mg-T12475-Ab | Mouse | Anti-Mouse GNRHR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-cynog-T12475-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque GNRHR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-felg-T12475-Ab | Cat/Feline | Anti-Cat/Feline GNRHR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-cang-T12475-Ab | Dog/Canine | Anti-Dog/Canine GNRHR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-bovg-T12475-Ab | Bovines/Cattle | Anti-Bovines/Cattle GNRHR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-equg-T12475-Ab | Equine/Horse | Anti-Equine/Horse GNRHR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GNRHR VLP (virus-like particle)
Cat No. | Species | Antigen Name | Expression Platform | Detail |
---|
GM-Tg-hg-T12475-Ag | Human | Human GNRHR VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-rg-T12475-Ag | Rat | Rat GNRHR VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-mg-T12475-Ag | Mouse | Mouse GNRHR VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-cynog-T12475-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque GNRHR VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-felg-T12475-Ag | Cat/Feline | Cat/Feline GNRHR VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-cang-T12475-Ag | Dog/Canine | Dog/Canine GNRHR VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-bovg-T12475-Ag | Bovines/Cattle | Bovines/Cattle GNRHR VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-equg-T12475-Ag | Equine/Horse | Equine/Horse GNRHR VLP (virus-like particle) | HEK293 | Products Developing |