Explore MLK3/MAP3K11 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T12126
|
| Target Name |
MLK3/MAP3K11
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
4296
|
| Gene ID |
100057319 (Equus caballus), 101098654 (Felis catus), 26403 (Mus musculus), 309168 (Rattus norvegicus)
4296 (Homo sapiens), 483732 (Canis lupus familiaris), 514210 (Bos taurus), 716038 (Macaca mulatta)
|
| Target Alternative Names |
MAP3K11,Map3k11,Mlk3,PTK1,SPRK,2610017K16Rik,RHOE,Mlk-3,MLK3,MLK-3,MEKK11
|
| Uniprot Accession |
Q80XI6,Q66HA1,Q16584
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
|
| Disease from KEGG |
MAPK signaling pathway
|
| Gene Ensembl |
ENSECAG00000010694, ENSMUSG00000004054, ENSG00000173327, ENSCAFG00845020324, ENSBTAG00000004114, ENSMMUG00000050788
|
| Target Classification |
Kinase
|
MLK3/MAP3K11 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo4296 | Pre-made Human MAP3K11/MLK3/PTK1 siRNA oligo Duplex | 4296 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo309168 | Pre-made Rat Map3k11/Mlk3/RHOE siRNA oligo Duplex | 309168 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo26403 | Pre-made Mouse Map3k11/Mlk3/PTK1 siRNA oligo Duplex | 26403 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo716038 | Pre-made Cynomolgus/Rhesus macaque MAP3K11 siRNA oligo Duplex | 716038 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101098654 | Pre-made Cat/Feline MAP3K11 siRNA oligo Duplex | 101098654 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo483732 | Pre-made Dog/Canine MAP3K11 siRNA oligo Duplex | 483732 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo514210 | Pre-made Bovines/Cattle MAP3K11 siRNA oligo Duplex | 514210 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100057319 | Pre-made Equine/Horse MAP3K11 siRNA oligo Duplex | 100057319 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
MLK3/MAP3K11 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T12126-Ab | Human | Anti-Human MLK3/MAP3K11 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T12126-Ab | Rat | Anti-Rat MLK3/MAP3K11 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T12126-Ab | Mouse | Anti-Mouse MLK3/MAP3K11 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T12126-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque MLK3/MAP3K11 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T12126-Ab | Cat/Feline | Anti-Cat/Feline MLK3/MAP3K11 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T12126-Ab | Dog/Canine | Anti-Dog/Canine MLK3/MAP3K11 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T12126-Ab | Bovines/Cattle | Anti-Bovines/Cattle MLK3/MAP3K11 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T12126-Ab | Equine/Horse | Anti-Equine/Horse MLK3/MAP3K11 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
MLK3/MAP3K11 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T12126-Ag | Human | Human MLK3/MAP3K11 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T12126-Ag | Rat | Rat MLK3/MAP3K11 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T12126-Ag | Mouse | Mouse MLK3/MAP3K11 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T12126-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque MLK3/MAP3K11 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T12126-Ag | Cat/Feline | Cat/Feline MLK3/MAP3K11 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T12126-Ag | Dog/Canine | Dog/Canine MLK3/MAP3K11 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T12126-Ag | Bovines/Cattle | Bovines/Cattle MLK3/MAP3K11 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T12126-Ag | Equine/Horse | Equine/Horse MLK3/MAP3K11 recombinant protein | Mammalian cell | Detail |
