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Target
sublocation: Transmembrane Protein.
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T11911
|
| Target Name |
KCNN1
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
3780
|
| Gene ID |
100070531 (Equus caballus), 101085608 (Felis catus), 3780 (Homo sapiens), 408008 (Bos taurus) 484829 (Canis lupus familiaris), 54261 (Rattus norvegicus), 720091 (Macaca mulatta), 84036 (Mus musculus)
|
| Target Alternative Names |
KCNN1,KCa2.1,Kcnn1,SK1,SKCA1,SKCa 1,SKCa1,Small conductance calcium-activated potassium channel protein 1,hSK1
|
| Uniprot Accession |
Q92952,P70606,Q9EQR3
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Insulin secretion, GnRH secretion
|
| Gene Ensembl |
ENSECAG00000009050, ENSG00000105642, ENSBTAG00000008626, ENSCAFG00845024279, ENSMMUG00000007398, ENSMUSG00000002908
|
Pre-made viral vector of KCNN1 cDNA Clones/ORF Plasmid
KCNN1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3780 | Pre-made Human KCNN1/SK1/hSK1 siRNA oligo Duplex | 3780 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo54261 | Pre-made Rat Kcnn1/SK1/SKCa1 siRNA oligo Duplex | 54261 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo84036 | Pre-made Mouse Kcnn1/SK1/SKCa1 siRNA oligo Duplex | 84036 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo720091 | Pre-made Cynomolgus/Rhesus macaque KCNN1 siRNA oligo Duplex | 720091 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101085608 | Pre-made Cat/Feline KCNN1 siRNA oligo Duplex | 101085608 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo484829 | Pre-made Dog/Canine KCNN1 siRNA oligo Duplex | 484829 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo408008 | Pre-made Bovines/Cattle KCNN1 siRNA oligo Duplex | 408008 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100070531 | Pre-made Equine/Horse KCNN1 siRNA oligo Duplex | 100070531 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
KCNN1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T11911-Ab | Human | Anti-Human KCNN1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T11911-Ab | Rat | Anti-Rat KCNN1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T11911-Ab | Mouse | Anti-Mouse KCNN1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T11911-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque KCNN1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T11911-Ab | Cat/Feline | Anti-Cat/Feline KCNN1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T11911-Ab | Dog/Canine | Anti-Dog/Canine KCNN1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T11911-Ab | Bovines/Cattle | Anti-Bovines/Cattle KCNN1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T11911-Ab | Equine/Horse | Anti-Equine/Horse KCNN1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
KCNN1 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T11911-Ag | Human | Human KCNN1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T11911-Ag | Rat | Rat KCNN1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T11911-Ag | Mouse | Mouse KCNN1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T11911-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque KCNN1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T11911-Ag | Cat/Feline | Cat/Feline KCNN1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T11911-Ag | Dog/Canine | Dog/Canine KCNN1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T11911-Ag | Bovines/Cattle | Bovines/Cattle KCNN1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T11911-Ag | Equine/Horse | Equine/Horse KCNN1 VLP (virus-like particle) | HEK293 | Products Developing |