Explore ADRA2A gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Transmembrane Protein.
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. The alpha-2-adrenergic receptors are a type of adrenergic receptors (for adrenaline or epinephrine), which inhibit adenylate cyclase. These receptors include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. They are involved in regulating the release of neurotransmitter molecules from sympathetic nerves and from adrenergic neurons in the central nervous system. The sympathetic nervous system regulates cardiovascular function by activating adrenergic receptors in the heart, blood vessels and kidney. Studies in mouse revealed that both the alpha2A and alpha2C receptor subtypes were required for presynaptic transmitter release from the sympathetic nervous system in the heart and from central noradrenergic neurons. The alpha-2-adrenergic receptors are also involved in catecholamine signaling by extracellular regulated protein kinase 1 and 2 (ERK1/2) pathways. A clear association between the alpha-2-adrenergic receptor and disease has not been yet established. [provided by RefSeq, Sep 2019]
Target ID |
GM-T11448
|
Target Name |
ADRA2A
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
150
|
Gene ID |
100147119 (Equus caballus), 11551 (Mus musculus), 150 (Homo sapiens), 25083 (Rattus norvegicus) 282135 (Bos taurus), 486888 (Canis lupus familiaris), 664736 (Felis catus), 695684 (Macaca mulatta)
|
Target Alternative Names |
ADRA2A,Adra2a,Adra-2,Adra-2a,alpha2A,alpha2-C10,alpha2A-AR,alpha(2A)AR,ADRA2,ADRAR,FPLD8,ZNF32,ADRA2R,ALPHA2AAR,RG20,CA2-47,RATRG20
|
Uniprot Accession |
Q01338,P08913,P22909,Q28838
|
Uniprot Entry Name |
|
Protein Sub-location |
Transmembrane Protein
|
Category |
Therapeutics Target
|
Disease |
|
Disease from KEGG |
cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction
|
Gene Ensembl |
ENSECAG00000059760, ENSMUSG00000033717, ENSG00000150594, ENSBTAG00000039292, ENSCAFG00845029289, ENSMMUG00000041307
|
Target Classification |
GPCR
|
Pre-made viral vector of ADRA2A cDNA Clones/ORF Plasmid
ADRA2A siRNA/miRNA/oligo for RNA interfence (RNAi)
Cat No. | Product Name | GeneID | Species | Grade | Detail |
---|
pGMoligo150 | Pre-made Human ADRA2A/ADRA2/ADRAR siRNA oligo Duplex | 150 | Human | In-vitro grade; in-vivo grade | Detail |
pGMoligo25083 | Pre-made Rat Adra2a/RG20/CA2-47 siRNA oligo Duplex | 25083 | Rat | In-vitro grade; in-vivo grade | Detail |
pGMoligo11551 | Pre-made Mouse Adra2a/Adra-2/Adra-2a siRNA oligo Duplex | 11551 | Mouse | In-vitro grade; in-vivo grade | Detail |
pGMoligo695684 | Pre-made Cynomolgus/Rhesus macaque ADRA2A siRNA oligo Duplex | 695684 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
pGMoligo664736 | Pre-made Cat/Feline ADRA2A siRNA oligo Duplex | 664736 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
pGMoligo486888 | Pre-made Dog/Canine ADRA2A siRNA oligo Duplex | 486888 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
pGMoligo282135 | Pre-made Bovines/Cattle ADRA2A siRNA oligo Duplex | 282135 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
pGMoligo100147119 | Pre-made Equine/Horse ADRA2A siRNA oligo Duplex | 100147119 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
ADRA2A antibody/GMab
Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
---|
GM-Tg-hg-T11448-Ab | Human | Anti-Human ADRA2A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-rg-T11448-Ab | Rat | Anti-Rat ADRA2A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-mg-T11448-Ab | Mouse | Anti-Mouse ADRA2A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-cynog-T11448-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque ADRA2A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-felg-T11448-Ab | Cat/Feline | Anti-Cat/Feline ADRA2A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-cang-T11448-Ab | Dog/Canine | Anti-Dog/Canine ADRA2A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-bovg-T11448-Ab | Bovines/Cattle | Anti-Bovines/Cattle ADRA2A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-equg-T11448-Ab | Equine/Horse | Anti-Equine/Horse ADRA2A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
ADRA2A VLP (virus-like particle)
Cat No. | Species | Antigen Name | Expression Platform | Detail |
---|
GM-Tg-hg-T11448-Ag | Human | Human ADRA2A VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-rg-T11448-Ag | Rat | Rat ADRA2A VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-mg-T11448-Ag | Mouse | Mouse ADRA2A VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-cynog-T11448-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque ADRA2A VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-felg-T11448-Ag | Cat/Feline | Cat/Feline ADRA2A VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-cang-T11448-Ag | Dog/Canine | Dog/Canine ADRA2A VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-bovg-T11448-Ag | Bovines/Cattle | Bovines/Cattle ADRA2A VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-equg-T11448-Ag | Equine/Horse | Equine/Horse ADRA2A VLP (virus-like particle) | HEK293 | Products Developing |