Explore CRHR2 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]
| Target ID |
GM-T11011
|
| Target Name |
CRHR2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
1395
|
| Gene ID |
100055029 (Equus caballus), 101095242 (Felis catus), 12922 (Mus musculus), 1395 (Homo sapiens)
482384 (Canis lupus familiaris), 521831 (Bos taurus), 64680 (Rattus norvegicus), 697404 (Macaca mulatta)
|
| Target Alternative Names |
CRF-R 2,CRF-R-2,CRF-R2,CRF-RB,CRF2,CRFR-2,CRFR2,CRFR2alpha,CRFR2beta,CRH-R 2,CRH-R2),CRHR2,Corticotropin-releasing factor receptor 2,Corticotropin-releasing hormone receptor 2 (CRH-R-2,Crf2r,Crfr2,Crhr2,HM-CRF
|
| Uniprot Accession |
Q60748,Q13324,P47866
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
cAMP signaling pathway, Neuroactive ligand-receptor interaction, Cushing syndrome
|
| Gene Ensembl |
ENSECAG00000025098, ENSMUSG00000003476, ENSG00000106113, ENSCAFG00845020144, ENSBTAG00000014381, ENSMMUG00000011758
|
| Target Classification |
GPCR
|
Pre-made viral vector of CRHR2 cDNA Clones/ORF Plasmid
CRHR2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1395 | Pre-made Human CRHR2/CRF2/CRFR2 siRNA oligo Duplex | 1395 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo64680 | Pre-made Rat Crhr2/Crf2r/CRF-R 2 siRNA oligo Duplex | 64680 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12922 | Pre-made Mouse Crhr2/Crfr2/CRF-R2 siRNA oligo Duplex | 12922 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo697404 | Pre-made Cynomolgus/Rhesus macaque CRHR2 siRNA oligo Duplex | 697404 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101095242 | Pre-made Cat/Feline CRHR2 siRNA oligo Duplex | 101095242 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo482384 | Pre-made Dog/Canine CRHR2 siRNA oligo Duplex | 482384 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo521831 | Pre-made Bovines/Cattle CRHR2 siRNA oligo Duplex | 521831 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100055029 | Pre-made Equine/Horse CRHR2 siRNA oligo Duplex | 100055029 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CRHR2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T11011-Ab | Human | Anti-Human CRHR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T11011-Ab | Rat | Anti-Rat CRHR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T11011-Ab | Mouse | Anti-Mouse CRHR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T11011-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CRHR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T11011-Ab | Cat/Feline | Anti-Cat/Feline CRHR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T11011-Ab | Dog/Canine | Anti-Dog/Canine CRHR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T11011-Ab | Bovines/Cattle | Anti-Bovines/Cattle CRHR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T11011-Ab | Equine/Horse | Anti-Equine/Horse CRHR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
CRHR2 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T11011-Ag | Human | Human CRHR2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T11011-Ag | Rat | Rat CRHR2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T11011-Ag | Mouse | Mouse CRHR2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T11011-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CRHR2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T11011-Ag | Cat/Feline | Cat/Feline CRHR2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T11011-Ag | Dog/Canine | Dog/Canine CRHR2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T11011-Ag | Bovines/Cattle | Bovines/Cattle CRHR2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T11011-Ag | Equine/Horse | Equine/Horse CRHR2 VLP (virus-like particle) | HEK293 | Products Developing |
