Explore BMP6 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Differential expression of this gene may be associated with progression of breast and prostate cancer. Mutations in this gene may be associated with iron overload in human patients. [provided by RefSeq, Jul 2016]
Target ID |
GM-T10762
|
Target Name |
BMP6
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
654
|
Gene ID |
100033934 (Equus caballus), 101098870 (Felis catus), 12161 (Mus musculus), 25644 (Rattus norvegicus) 478715 (Canis lupus familiaris), 617566 (Bos taurus), 654 (Homo sapiens), 695091 (Macaca mulatta)
|
Target Alternative Names |
BMP-6,BMP6,Bmp6,Bone morphogenetic protein 6,D13Wsu115e,IO,VG-1-related protein (VG-1-R,VGR,VGR-1),VGR1,Vgr1
|
Uniprot Accession |
P20722,Q04906,P22004
|
Uniprot Entry Name |
|
Protein Sub-location |
Secreted Protein/Potential Cytokines
|
Category |
Therapeutics Target, Cytokine Target
|
Disease |
cancer
|
Disease from KEGG |
Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Hippo signaling pathway, Ovarian steroidogenesis
|
Gene Ensembl |
ENSECAG00000020015, ENSMUSG00000039004, ENSCAFG00845017586, ENSBTAG00000019234, ENSG00000153162, ENSMMUG00000021600
|
Target Classification |
|
Pre-made viral vector of BMP6 cDNA Clones/ORF Plasmid
BMP6 siRNA/miRNA/oligo for RNA interfence (RNAi)
Cat No. | Product Name | GeneID | Species | Grade | Detail |
---|
pGMoligo654 | Pre-made Human BMP6/IO/VGR siRNA oligo Duplex | 654 | Human | In-vitro grade; in-vivo grade | Detail |
pGMoligo25644 | Pre-made Rat Bmp6/VGR siRNA oligo Duplex | 25644 | Rat | In-vitro grade; in-vivo grade | Detail |
pGMoligo12161 | Pre-made Mouse Bmp6/Vgr1/D13Wsu115e siRNA oligo Duplex | 12161 | Mouse | In-vitro grade; in-vivo grade | Detail |
pGMoligo695091 | Pre-made Cynomolgus/Rhesus macaque BMP6 siRNA oligo Duplex | 695091 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
pGMoligo101098870 | Pre-made Cat/Feline BMP6 siRNA oligo Duplex | 101098870 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
pGMoligo478715 | Pre-made Dog/Canine BMP6 siRNA oligo Duplex | 478715 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
pGMoligo617566 | Pre-made Bovines/Cattle BMP6 siRNA oligo Duplex | 617566 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
pGMoligo100033934 | Pre-made Equine/Horse BMP6 siRNA oligo Duplex | 100033934 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
BMP6 antibody/GMab
Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
---|
GM-Tg-hg-T10762-Ab | Human | Anti-Human BMP6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-rg-T10762-Ab | Rat | Anti-Rat BMP6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-mg-T10762-Ab | Mouse | Anti-Mouse BMP6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-cynog-T10762-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque BMP6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-felg-T10762-Ab | Cat/Feline | Anti-Cat/Feline BMP6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-cang-T10762-Ab | Dog/Canine | Anti-Dog/Canine BMP6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-bovg-T10762-Ab | Bovines/Cattle | Anti-Bovines/Cattle BMP6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
GM-Tg-equg-T10762-Ab | Equine/Horse | Anti-Equine/Horse BMP6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
BMP6 recombinant protein
Cat No. | Species | Antigen Name | Expression Platform | Detail |
---|
GM-Tg-hg-T10762-Ag | Human | Human BMP6 recombinant protein | Mammalian cell | Detail |
GM-Tg-rg-T10762-Ag | Rat | Rat BMP6 recombinant protein | Mammalian cell | Detail |
GM-Tg-mg-T10762-Ag | Mouse | Mouse BMP6 recombinant protein | Mammalian cell | Detail |
GM-Tg-cynog-T10762-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque BMP6 recombinant protein | Mammalian cell | Detail |
GM-Tg-felg-T10762-Ag | Cat/Feline | Cat/Feline BMP6 recombinant protein | Mammalian cell | Detail |
GM-Tg-cang-T10762-Ag | Dog/Canine | Dog/Canine BMP6 recombinant protein | Mammalian cell | Detail |
GM-Tg-bovg-T10762-Ag | Bovines/Cattle | Bovines/Cattle BMP6 recombinant protein | Mammalian cell | Detail |
GM-Tg-equg-T10762-Ag | Equine/Horse | Equine/Horse BMP6 recombinant protein | Mammalian cell | Detail |