Explore CD18/ITGB2 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
| Target ID |
GM-T10513
|
| Target Name |
CD18/ITGB2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3689
|
| Gene ID |
100056128 (Equus caballus), 101087258 (Felis catus), 16414 (Mus musculus), 281877 (Bos taurus)
309684 (Rattus norvegicus), 3689 (Homo sapiens), 403770 (Canis lupus familiaris), 710577 (Macaca mulatta)
|
| Target Alternative Names |
2E6,95 subunit beta,CD18,Cd18,Cell surface adhesion glycoproteins LFA-1/CR3/p150,Complement receptor C3 subunit beta,ITGB2,Integrin beta-2,Itgb2,LAD,LCAMB,LFA-1,Lfa1,MAC-1,MF17,MFI7
|
| Uniprot Accession |
P11835,P32592,P05107
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, INN Index
|
| Disease |
cancer
|
| Disease from KEGG |
Rap1 signaling pathway, Phagosome, Hippo signaling pathway, Cell adhesion molecules, Complement and coagulation cascades, Natural killer cell mediated cytotoxicity, Leukocyte transendothelial migration, Regulation of actin cytoskeleton, Pertussis, Legionellosis, Leishmaniasis, Malaria, Amoebiasis, Staphylococcus aureus infection, Tuberculosis, Human T-cell leukemia virus 1 infection, Rheumatoid arthritis, Viral myocarditis
|
| Gene Ensembl |
ENSECAG00000023061, ENSMUSG00000000290, ENSBTAG00000017060, ENSG00000160255, ENSCAFG00845021592, ENSMMUG00000000951
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of CD18/ITGB2 cDNA Clones/ORF Plasmid
CD18/ITGB2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3689 | Pre-made Human ITGB2/LAD/CD18 siRNA oligo Duplex | 3689 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo309684 | Pre-made Rat Itgb2/Cd18 siRNA oligo Duplex | 309684 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16414 | Pre-made Mouse Itgb2/2E6/LAD siRNA oligo Duplex | 16414 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo710577 | Pre-made Cynomolgus/Rhesus macaque ITGB2 siRNA oligo Duplex | 710577 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101087258 | Pre-made Cat/Feline ITGB2 siRNA oligo Duplex | 101087258 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403770 | Pre-made Dog/Canine ITGB2 siRNA oligo Duplex | 403770 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281877 | Pre-made Bovines/Cattle ITGB2/CD18 siRNA oligo Duplex | 281877 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100056128 | Pre-made Equine/Horse ITGB2 siRNA oligo Duplex | 100056128 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CD18/ITGB2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T10513-Ab | Human | Anti-Human CD18/ITGB2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T10513-Ab | Rat | Anti-Rat CD18/ITGB2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T10513-Ab | Mouse | Anti-Mouse CD18/ITGB2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T10513-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CD18/ITGB2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T10513-Ab | Cat/Feline | Anti-Cat/Feline CD18/ITGB2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T10513-Ab | Dog/Canine | Anti-Dog/Canine CD18/ITGB2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T10513-Ab | Bovines/Cattle | Anti-Bovines/Cattle CD18/ITGB2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T10513-Ab | Equine/Horse | Anti-Equine/Horse CD18/ITGB2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
CD18/ITGB2 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T10513-Ag | Human | Human CD18/ITGB2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T10513-Ag | Rat | Rat CD18/ITGB2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T10513-Ag | Mouse | Mouse CD18/ITGB2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T10513-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CD18/ITGB2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T10513-Ag | Cat/Feline | Cat/Feline CD18/ITGB2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T10513-Ag | Dog/Canine | Dog/Canine CD18/ITGB2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T10513-Ag | Bovines/Cattle | Bovines/Cattle CD18/ITGB2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T10513-Ag | Equine/Horse | Equine/Horse CD18/ITGB2 VLP (virus-like particle) | HEK293 | Products Developing |
