Explore CD4 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene encodes the CD4 membrane glycoprotein of T lymphocytes. The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules. The CD4 antigen is also a primary receptor for entry of the human immunodeficiency virus through interactions with the HIV Env gp120 subunit. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, granulocytes, as well as in various regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, May 2020]
| Target ID |
GM-T10191
|
| Target Name |
CD4
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
920
|
| Gene ID |
100052502 (Equus caballus), 12504 (Mus musculus), 24932 (Rattus norvegicus), 403931 (Canis lupus familiaris) 407098 (Bos taurus), 493775 (Felis catus), 713807 (Macaca mulatta), 920 (Homo sapiens)
|
| Target Alternative Names |
CD4,CD4mut,Cd4,IMD79,L3T4,Leu-3,Ly-4,OKT4D,T-cell surface antigen T4/Leu-3,T-cell surface glycoprotein CD4,T4,W3/25,p55
|
| Uniprot Accession |
P06332,P05540,P33705,P16003,P01730
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target, INN Index
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, Cell adhesion molecules, Antigen processing and presentation, Hematopoietic cell lineage, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Yersinia infection, Human T-cell leukemia virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer
|
| Gene Ensembl |
ENSECAG00000009049, ENSMUSG00000023274, ENSCAFG00845027739, ENSBTAG00000003255, ENSMMUG00000013202, ENSG00000010610
|
| Target Classification |
Checkpoint-Immuno Oncology
|
Pre-made viral vector of CD4 cDNA Clones/ORF Plasmid
CD4 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo920 | Pre-made Human CD4/T4/IMD79 siRNA oligo Duplex | 920 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24932 | Pre-made Rat Cd4/p55/W3/25 siRNA oligo Duplex | 24932 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12504 | Pre-made Mouse Cd4/L3T4/Ly-4 siRNA oligo Duplex | 12504 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo713807 | Pre-made Cynomolgus/Rhesus macaque CD4 siRNA oligo Duplex | 713807 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo493775 | Pre-made Cat/Feline CD4 siRNA oligo Duplex | 493775 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403931 | Pre-made Dog/Canine CD4 siRNA oligo Duplex | 403931 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo407098 | Pre-made Bovines/Cattle CD4 siRNA oligo Duplex | 407098 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100052502 | Pre-made Equine/Horse CD4 siRNA oligo Duplex | 100052502 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CD4 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T10191-Ab | Human | Anti-Human CD4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T10191-Ab | Rat | Anti-Rat CD4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T10191-Ab | Mouse | Anti-Mouse CD4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T10191-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CD4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T10191-Ab | Cat/Feline | Anti-Cat/Feline CD4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T10191-Ab | Dog/Canine | Anti-Dog/Canine CD4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T10191-Ab | Bovines/Cattle | Anti-Bovines/Cattle CD4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T10191-Ab | Equine/Horse | Anti-Equine/Horse CD4 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
CD4 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T10191-Ag | Human | Human CD4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T10191-Ag | Rat | Rat CD4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T10191-Ag | Mouse | Mouse CD4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T10191-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CD4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T10191-Ag | Cat/Feline | Cat/Feline CD4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T10191-Ag | Dog/Canine | Dog/Canine CD4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T10191-Ag | Bovines/Cattle | Bovines/Cattle CD4 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T10191-Ag | Equine/Horse | Equine/Horse CD4 VLP (virus-like particle) | HEK293 | Products Developing |