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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T09826
|
| Target Name |
TOP1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
7150
|
| Gene ID |
100070532 (Equus caballus), 101093174 (Felis catus), 21969 (Mus musculus), 477229 (Canis lupus familiaris)
534799 (Bos taurus), 64550 (Rattus norvegicus), 697300 (Macaca mulatta), 7150 (Homo sapiens)
|
| Target Alternative Names |
Ab2-086,D130064I21Rik,DNA topoisomerase 1,DNA topoisomerase I,TOP,TOP1,TOPI,Top-1,Top1
|
| Uniprot Accession |
Q04750,Q9WUL0,P11387
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Gene Ensembl |
ENSECAG00000000383, ENSMUSG00000070544, ENSCAFG00845029978, ENSBTAG00000007960, ENSMMUG00000011112, ENSG00000198900
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of TOP1 cDNA Clones/ORF Plasmid
TOP1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo7150 | Pre-made Human TOP1/TOPI siRNA oligo Duplex | 7150 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo64550 | Pre-made Rat Top1/Ab2-086 siRNA oligo Duplex | 64550 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo21969 | Pre-made Mouse Top1/Top-1/D130064I21Rik siRNA oligo Duplex | 21969 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo697300 | Pre-made Cynomolgus/Rhesus macaque TOP1 siRNA oligo Duplex | 697300 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101093174 | Pre-made Cat/Feline TOP1 siRNA oligo Duplex | 101093174 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo477229 | Pre-made Dog/Canine TOP1/TOP siRNA oligo Duplex | 477229 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo534799 | Pre-made Bovines/Cattle TOP1 siRNA oligo Duplex | 534799 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100070532 | Pre-made Equine/Horse TOP1 siRNA oligo Duplex | 100070532 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
TOP1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T09826-Ab | Human | Anti-Human TOP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T09826-Ab | Rat | Anti-Rat TOP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T09826-Ab | Mouse | Anti-Mouse TOP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T09826-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque TOP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T09826-Ab | Cat/Feline | Anti-Cat/Feline TOP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T09826-Ab | Dog/Canine | Anti-Dog/Canine TOP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T09826-Ab | Bovines/Cattle | Anti-Bovines/Cattle TOP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T09826-Ab | Equine/Horse | Anti-Equine/Horse TOP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
TOP1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T09826-Ag | Human | Human TOP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T09826-Ag | Rat | Rat TOP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T09826-Ag | Mouse | Mouse TOP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T09826-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque TOP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T09826-Ag | Cat/Feline | Cat/Feline TOP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T09826-Ag | Dog/Canine | Dog/Canine TOP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T09826-Ag | Bovines/Cattle | Bovines/Cattle TOP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T09826-Ag | Equine/Horse | Equine/Horse TOP1 recombinant protein | Mammalian cell | Detail |
