Explore MC2R gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. Alternate transcript variants have been found for this gene. [provided by RefSeq, May 2014]
| Target ID |
GM-T08898
|
| Target Name |
MC2R
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
4158
|
| Gene ID |
100057018 (Equus caballus), 100855756 (Canis lupus familiaris), 114673757 (Macaca mulatta), 17200 (Mus musculus)
281299 (Bos taurus), 282839 (Rattus norvegicus), 4158 (Homo sapiens), 692350 (Felis catus)
|
| Target Alternative Names |
ACTH receptor,ACTH-R,ACTHR,Adrenocorticotropic hormone receptor,Adrenocorticotropin receptor,MC2-R,MC2R,Mc2r,Melanocortin receptor 2 (MC2-R)
|
| Uniprot Accession |
Q64326,P34974,Q01718
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
cAMP signaling pathway, Neuroactive ligand-receptor interaction, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, Cushing syndrome
|
| Gene Ensembl |
ENSECAG00000003841, ENSCAFG00845003453, ENSMUSG00000045569, ENSBTAG00000011038, ENSG00000185231
|
| Target Classification |
GPCR, Tumor-associated antigen (TAA)
|
MC2R siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo4158 | Pre-made Human MC2R/ACTHR siRNA oligo Duplex | 4158 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo282839 | Pre-made Rat Mc2r siRNA oligo Duplex | 282839 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo17200 | Pre-made Mouse Mc2r/ACTHR/MC2-R siRNA oligo Duplex | 17200 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo114673757 | Pre-made Cynomolgus/Rhesus macaque MC2R siRNA oligo Duplex | 114673757 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo692350 | Pre-made Cat/Feline MC2R/ACTHR siRNA oligo Duplex | 692350 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100855756 | Pre-made Dog/Canine MC2R siRNA oligo Duplex | 100855756 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281299 | Pre-made Bovines/Cattle MC2R siRNA oligo Duplex | 281299 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100057018 | Pre-made Equine/Horse MC2R siRNA oligo Duplex | 100057018 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
MC2R antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T08898-Ab | Human | Anti-Human MC2R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T08898-Ab | Rat | Anti-Rat MC2R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T08898-Ab | Mouse | Anti-Mouse MC2R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T08898-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque MC2R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T08898-Ab | Cat/Feline | Anti-Cat/Feline MC2R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T08898-Ab | Dog/Canine | Anti-Dog/Canine MC2R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T08898-Ab | Bovines/Cattle | Anti-Bovines/Cattle MC2R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T08898-Ab | Equine/Horse | Anti-Equine/Horse MC2R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
MC2R VLP (virus-like particle)
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T08898-Ag | Human | Human MC2R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T08898-Ag | Rat | Rat MC2R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T08898-Ag | Mouse | Mouse MC2R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T08898-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque MC2R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T08898-Ag | Cat/Feline | Cat/Feline MC2R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T08898-Ag | Dog/Canine | Dog/Canine MC2R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T08898-Ag | Bovines/Cattle | Bovines/Cattle MC2R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T08898-Ag | Equine/Horse | Equine/Horse MC2R VLP (virus-like particle) | HEK293 | Products Developing |
