Explore CDK12/CRKRS gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Introcelluar Protein.
Enables RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin binding activity. Involved in phosphorylation of RNA polymerase II C-terminal domain; protein autophosphorylation; and regulation of MAP kinase activity. Located in nuclear speck. Part of cyclin K-CDK12 complex. [provided by Alliance of Genome Resources, Apr 2022]
| Target ID |
GM-T08326
|
| Target Name |
CDK12/CRKRS
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
51755
|
| Gene ID |
100068316 (Equus caballus), 101090563 (Felis catus), 192350 (Rattus norvegicus), 491027 (Canis lupus familiaris)
511513 (Bos taurus), 51755 (Homo sapiens), 69131 (Mus musculus), 696733 (Macaca mulatta)
|
| Target Alternative Names |
1810022J16Rik,CDK12,CRK7,CRKR,CRKRS,Cdc2-related kinase,Cdk12,Cell division cycle 2-related protein kinase 7 (CDC2-related protein kinase 7),Cell division protein kinase 12 (hCDK12),Crk7,Crkrs,Cyclin-dependent kinase 12,D11Ertd752e,Hgn,Pksc,arginine/serine-rich (CrkRS)
|
| Uniprot Accession |
Q3MJK5,E1BB50,Q9NYV4,Q14AX6
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Gene Ensembl |
ENSECAG00000021449, ENSCAFG00845012790, ENSBTAG00000013238, ENSG00000167258, ENSMUSG00000003119, ENSMMUG00000021350
|
| Target Classification |
Kinase, Tumor-associated antigen (TAA)
|
CDK12/CRKRS siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo51755 | Pre-made Human CDK12/CRK7/CRKR siRNA oligo Duplex | 51755 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo192350 | Pre-made Rat Cdk12/Hgn/Crk7 siRNA oligo Duplex | 192350 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo69131 | Pre-made Mouse Cdk12/Crk7/Pksc siRNA oligo Duplex | 69131 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo696733 | Pre-made Cynomolgus/Rhesus macaque CDK12/CRKRS siRNA oligo Duplex | 696733 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101090563 | Pre-made Cat/Feline CDK12 siRNA oligo Duplex | 101090563 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo491027 | Pre-made Dog/Canine CDK12/CRKRS siRNA oligo Duplex | 491027 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo511513 | Pre-made Bovines/Cattle CDK12/CRKRS siRNA oligo Duplex | 511513 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100068316 | Pre-made Equine/Horse CDK12 siRNA oligo Duplex | 100068316 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CDK12/CRKRS antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T08326-Ab | Human | Anti-Human CDK12/CRKRS monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T08326-Ab | Rat | Anti-Rat CDK12/CRKRS monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T08326-Ab | Mouse | Anti-Mouse CDK12/CRKRS monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T08326-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CDK12/CRKRS monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T08326-Ab | Cat/Feline | Anti-Cat/Feline CDK12/CRKRS monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T08326-Ab | Dog/Canine | Anti-Dog/Canine CDK12/CRKRS monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T08326-Ab | Bovines/Cattle | Anti-Bovines/Cattle CDK12/CRKRS monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T08326-Ab | Equine/Horse | Anti-Equine/Horse CDK12/CRKRS monoclonal antibody | mab | Therapeutics Target antibody | Detail |
CDK12/CRKRS recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T08326-Ag | Human | Human CDK12/CRKRS recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T08326-Ag | Rat | Rat CDK12/CRKRS recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T08326-Ag | Mouse | Mouse CDK12/CRKRS recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T08326-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CDK12/CRKRS recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T08326-Ag | Cat/Feline | Cat/Feline CDK12/CRKRS recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T08326-Ag | Dog/Canine | Dog/Canine CDK12/CRKRS recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T08326-Ag | Bovines/Cattle | Bovines/Cattle CDK12/CRKRS recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T08326-Ag | Equine/Horse | Equine/Horse CDK12/CRKRS recombinant protein | Mammalian cell | Detail |
