Explore APOB gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins (LDL), and is the ligand for the LDL receptor. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [provided by RefSeq, Dec 2019]
Target ID |
GM-T07533
|
Target Name |
APOB
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
338
|
Gene ID |
100071824 (Equus caballus), 101098863 (Felis catus), 238055 (Mus musculus), 338 (Homo sapiens) 475680 (Canis lupus familiaris), 494004 (Bos taurus), 54225 (Rattus norvegicus), 702937 (Macaca mulatta)
|
Target Alternative Names |
APOB,Apob,apoB-100,apob-48,apob-100,Apo B-100,FLDB,FCHL2,LDLCQ4,apoB-48,APOB-100,ApoB(100),Aa1064,Ac1-060,ApoB-48,ApoB-100
|
Uniprot Accession |
E9Q414,P04114,Q7TMA5
|
Uniprot Entry Name |
|
Protein Sub-location |
Transmembrane Protein
|
Category |
Therapeutics Target
|
Disease |
cancer, Ovary Cancer
|
Disease from KEGG |
Fat digestion and absorption, Vitamin digestion and absorption, Cholesterol metabolism, Lipid and atherosclerosis
|
Gene Ensembl |
ENSECAG00000008600, ENSMUSG00000020609, ENSG00000084674, ENSCAFG00845020315, ENSBTAG00000008505, ENSMMUG00000007692
|
Target Classification |
|
APOB siRNA/miRNA/oligo for RNA interfence (RNAi)
Cat No. | Product Name | GeneID | Species | Grade | Detail |
---|
pGMoligo338 | Pre-made Human APOB/FLDB/FCHL2 siRNA oligo Duplex | 338 | Human | In-vitro grade; in-vivo grade | Detail |
pGMoligo54225 | Pre-made Rat Apob/Aa1064/Ac1-060 siRNA oligo Duplex | 54225 | Rat | In-vitro grade; in-vivo grade | Detail |
pGMoligo238055 | Pre-made Mouse Apob/apob-48/apob-100 siRNA oligo Duplex | 238055 | Mouse | In-vitro grade; in-vivo grade | Detail |
pGMoligo702937 | Pre-made Cynomolgus/Rhesus macaque APOB siRNA oligo Duplex | 702937 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
pGMoligo101098863 | Pre-made Cat/Feline APOB siRNA oligo Duplex | 101098863 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
pGMoligo475680 | Pre-made Dog/Canine APOB siRNA oligo Duplex | 475680 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
pGMoligo494004 | Pre-made Bovines/Cattle APOB/APOB-100/ApoB(100) siRNA oligo Duplex | 494004 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
pGMoligo100071824 | Pre-made Equine/Horse APOB/apoB-100 siRNA oligo Duplex | 100071824 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
APOB antibody/GMab
Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
---|
GM-Tg-hg-T07533-Ab | Human | Anti-Human APOB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-rg-T07533-Ab | Rat | Anti-Rat APOB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-mg-T07533-Ab | Mouse | Anti-Mouse APOB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-cynog-T07533-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque APOB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-felg-T07533-Ab | Cat/Feline | Anti-Cat/Feline APOB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-cang-T07533-Ab | Dog/Canine | Anti-Dog/Canine APOB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-bovg-T07533-Ab | Bovines/Cattle | Anti-Bovines/Cattle APOB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-equg-T07533-Ab | Equine/Horse | Anti-Equine/Horse APOB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
APOB VLP (virus-like particle)
Cat No. | Species | Antigen Name | Expression Platform | Detail |
---|
GM-Tg-hg-T07533-Ag | Human | Human APOB VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-rg-T07533-Ag | Rat | Rat APOB VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-mg-T07533-Ag | Mouse | Mouse APOB VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-cynog-T07533-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque APOB VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-felg-T07533-Ag | Cat/Feline | Cat/Feline APOB VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-cang-T07533-Ag | Dog/Canine | Dog/Canine APOB VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-bovg-T07533-Ag | Bovines/Cattle | Bovines/Cattle APOB VLP (virus-like particle) | HEK293 | Products Developing |
GM-Tg-equg-T07533-Ag | Equine/Horse | Equine/Horse APOB VLP (virus-like particle) | HEK293 | Products Developing |