Explore PDGFA gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
| Target ID |
GM-T06869
|
| Target Name |
PDGFA
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
5154
|
| Gene ID |
100055086 (Equus caballus), 101087287 (Felis catus), 18590 (Mus musculus), 25266 (Rattus norvegicus)
491597 (Canis lupus familiaris), 505908 (Bos taurus), 5154 (Homo sapiens), 707725 (Macaca mulatta)
|
| Target Alternative Names |
PDGF subunit A,PDGF-1,PDGF-A,PDGF1,PDGFA,PDGFACP,Pdgfa,Platelet-derived growth factor A chain,Platelet-derived growth factor alpha polypeptide,Platelet-derived growth factor subunit A
|
| Uniprot Accession |
P20033,P28576,Q2KJ15,P04085
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target, Cytokine Target
|
| Disease |
cancer, Breast Cancer, Type 1 diabetes mellitus
|
| Disease from KEGG |
EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, Pathways in cancer, Glioma, Prostate cancer, Melanoma, Choline metabolism in cancer, Fluid shear stress and atherosclerosis
|
| Gene Ensembl |
ENSECAG00000038632, ENSMUSG00000025856, ENSBTAG00000014541, ENSG00000197461, ENSMMUG00000004949
|
Pre-made viral vector of PDGFA cDNA Clones/ORF Plasmid
PDGFA siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5154 | Pre-made Human PDGFA/PDGF1/PDGF-A siRNA oligo Duplex | 5154 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25266 | Pre-made Rat Pdgfa/PDGFACP siRNA oligo Duplex | 25266 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo18590 | Pre-made Mouse Pdgfa/PDGF-1 siRNA oligo Duplex | 18590 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo707725 | Pre-made Cynomolgus/Rhesus macaque PDGFA siRNA oligo Duplex | 707725 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101087287 | Pre-made Cat/Feline PDGFA siRNA oligo Duplex | 101087287 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo491597 | Pre-made Dog/Canine PDGFA siRNA oligo Duplex | 491597 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo505908 | Pre-made Bovines/Cattle PDGFA siRNA oligo Duplex | 505908 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100055086 | Pre-made Equine/Horse PDGFA siRNA oligo Duplex | 100055086 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PDGFA antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T06869-Ab | Human | Anti-Human PDGFA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T06869-Ab | Rat | Anti-Rat PDGFA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T06869-Ab | Mouse | Anti-Mouse PDGFA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T06869-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PDGFA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T06869-Ab | Cat/Feline | Anti-Cat/Feline PDGFA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T06869-Ab | Dog/Canine | Anti-Dog/Canine PDGFA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T06869-Ab | Bovines/Cattle | Anti-Bovines/Cattle PDGFA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T06869-Ab | Equine/Horse | Anti-Equine/Horse PDGFA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
PDGFA recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T06869-Ag | Human | Human PDGFA recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T06869-Ag | Rat | Rat PDGFA recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T06869-Ag | Mouse | Mouse PDGFA recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T06869-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PDGFA recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T06869-Ag | Cat/Feline | Cat/Feline PDGFA recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T06869-Ag | Dog/Canine | Dog/Canine PDGFA recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T06869-Ag | Bovines/Cattle | Bovines/Cattle PDGFA recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T06869-Ag | Equine/Horse | Equine/Horse PDGFA recombinant protein | Mammalian cell | Detail |
