Explore IFNAR2 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family. Mutations in this gene are associated with Immunodeficiency 45. [provided by RefSeq, Jul 2020]
| Target ID |
GM-T06421
|
| Target Name |
IFNAR2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3455
|
| Gene ID |
100052489 (Equus caballus), 100856468 (Canis lupus familiaris), 101090285 (Felis catus), 15976 (Mus musculus)
282258 (Bos taurus), 3455 (Homo sapiens), 686326 (Rattus norvegicus), 699726 (Macaca mulatta)
|
| Target Alternative Names |
IFN-R,IFN-R-2,IFN-alpha binding protein,IFN-alpha-REC,IFN-alpha/beta receptor 2,IFNABR,IFNAR2,IFNARB,IFNBR,IL10RB,IMD45,Ifnar-2,Ifnar2,Interferon alpha binding protein,Interferon alpha/beta receptor 2,Type I interferon receptor 2
|
| Uniprot Accession |
O35664,Q95141,P48551
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target, Cytokine Target
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, Hepatitis C, Measles, Influenza A, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Epstein-Barr virus infection, Pathways in cancer
|
| Gene Ensembl |
ENSECAG00000003532, ENSCAFG00845026478, ENSMUSG00000022971, ENSBTAG00000015212, ENSG00000159110, ENSMMUG00000003956
|
| Target Classification |
Cytokine Receptor, Checkpoint-Immuno Oncology
|
Pre-made viral vector of IFNAR2 cDNA Clones/ORF Plasmid
IFNAR2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3455 | Pre-made Human IFNAR2/IFN-R/IMD45 siRNA oligo Duplex | 3455 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo686326 | Pre-made Rat Ifnar2 siRNA oligo Duplex | 686326 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo15976 | Pre-made Mouse Ifnar2/IFN-R-2/Ifnar-2 siRNA oligo Duplex | 15976 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo699726 | Pre-made Cynomolgus/Rhesus macaque IFNAR2/IL10RB siRNA oligo Duplex | 699726 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101090285 | Pre-made Cat/Feline IFNAR2 siRNA oligo Duplex | 101090285 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100856468 | Pre-made Dog/Canine IFNAR2 siRNA oligo Duplex | 100856468 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo282258 | Pre-made Bovines/Cattle IFNAR2/IFN-R/IFNBR siRNA oligo Duplex | 282258 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100052489 | Pre-made Equine/Horse IFNAR2 siRNA oligo Duplex | 100052489 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
IFNAR2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T06421-Ab | Human | Anti-Human IFNAR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T06421-Ab | Rat | Anti-Rat IFNAR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T06421-Ab | Mouse | Anti-Mouse IFNAR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T06421-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque IFNAR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T06421-Ab | Cat/Feline | Anti-Cat/Feline IFNAR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T06421-Ab | Dog/Canine | Anti-Dog/Canine IFNAR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T06421-Ab | Bovines/Cattle | Anti-Bovines/Cattle IFNAR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T06421-Ab | Equine/Horse | Anti-Equine/Horse IFNAR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
IFNAR2 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T06421-Ag | Human | Human IFNAR2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T06421-Ag | Rat | Rat IFNAR2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T06421-Ag | Mouse | Mouse IFNAR2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T06421-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque IFNAR2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T06421-Ag | Cat/Feline | Cat/Feline IFNAR2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T06421-Ag | Dog/Canine | Dog/Canine IFNAR2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T06421-Ag | Bovines/Cattle | Bovines/Cattle IFNAR2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T06421-Ag | Equine/Horse | Equine/Horse IFNAR2 VLP (virus-like particle) | HEK293 | Products Developing |
