Explore ROCK2 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T06093
|
| Target Name |
ROCK2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
9475
|
| Gene ID |
100072339 (Equus caballus), 101094501 (Felis catus), 19878 (Mus musculus), 25537 (Rattus norvegicus)
282041 (Bos taurus), 482970 (Canis lupus familiaris), 708444 (Macaca mulatta), 9475 (Homo sapiens)
|
| Target Alternative Names |
B230113H15Rik,ROCK-II,ROCK2,ROK,ROKalpha,Rho kinase 2,Rho-associated,Rho-associated protein kinase 2,Rho-kinase,Rock-II,Rock2,Rock2m,coiled-coil-containing protein kinase 2,coiled-coil-containing protein kinase II (ROCK-II),mKIAA0619,p164 ROCK-2
|
| Uniprot Accession |
P70336,Q62868,Q28021,O75116
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
cGMP-PKG signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, Wnt signaling pathway, Axon guidance, Focal adhesion, Tight junction, Platelet activation, Leukocyte transendothelial migration, Regulation of actin cytoskeleton, Oxytocin signaling pathway, Pathogenic Escherichia coli infection, Yersinia infection, Human cytomegalovirus infection, Pathways in cancer, Proteoglycans in cancer, Lipid and atherosclerosis
|
| Gene Ensembl |
ENSECAG00000009872, ENSMUSG00000020580, ENSBTAG00000005847, ENSCAFG00845027461, ENSMMUG00000016678, ENSG00000134318
|
| Target Classification |
Kinase
|
Pre-made viral vector of ROCK2 cDNA Clones/ORF Plasmid
ROCK2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo9475 | Pre-made Human ROCK2/ROCK-II siRNA oligo Duplex | 9475 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25537 | Pre-made Rat Rock2/ROK/ROCK-II siRNA oligo Duplex | 25537 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo19878 | Pre-made Mouse Rock2/Rock2m/Rock-II siRNA oligo Duplex | 19878 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo708444 | Pre-made Cynomolgus/Rhesus macaque ROCK2 siRNA oligo Duplex | 708444 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101094501 | Pre-made Cat/Feline ROCK2 siRNA oligo Duplex | 101094501 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo482970 | Pre-made Dog/Canine ROCK2 siRNA oligo Duplex | 482970 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo282041 | Pre-made Bovines/Cattle ROCK2/ROCK-II siRNA oligo Duplex | 282041 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100072339 | Pre-made Equine/Horse ROCK2 siRNA oligo Duplex | 100072339 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
ROCK2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T06093-Ab | Human | Anti-Human ROCK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T06093-Ab | Rat | Anti-Rat ROCK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T06093-Ab | Mouse | Anti-Mouse ROCK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T06093-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque ROCK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T06093-Ab | Cat/Feline | Anti-Cat/Feline ROCK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T06093-Ab | Dog/Canine | Anti-Dog/Canine ROCK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T06093-Ab | Bovines/Cattle | Anti-Bovines/Cattle ROCK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T06093-Ab | Equine/Horse | Anti-Equine/Horse ROCK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
ROCK2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T06093-Ag | Human | Human ROCK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T06093-Ag | Rat | Rat ROCK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T06093-Ag | Mouse | Mouse ROCK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T06093-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque ROCK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T06093-Ag | Cat/Feline | Cat/Feline ROCK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T06093-Ag | Dog/Canine | Dog/Canine ROCK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T06093-Ag | Bovines/Cattle | Bovines/Cattle ROCK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T06093-Ag | Equine/Horse | Equine/Horse ROCK2 recombinant protein | Mammalian cell | Detail |
