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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Introcelluar Protein.
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T05090
|
| Target Name |
HDAC3
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
8841
|
| Gene ID |
100061405 (Equus caballus), 101100941 (Felis catus), 15183 (Mus musculus), 404125 (Bos taurus) 478040 (Canis lupus familiaris), 704467 (Macaca mulatta), 84578 (Rattus norvegicus), 8841 (Homo sapiens)
|
| Target Alternative Names |
HD3,HDAC3,Hdac3,Histone deacetylase 3,KDAC3,Protein deacetylase HDAC3,Protein deacylase HDAC3,RPD3,RPD3-2,SMAP45
|
| Uniprot Accession |
O88895,Q6P6W3,O15379
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Thyroid hormone signaling pathway
|
| Gene Ensembl |
ENSECAG00000020589, ENSMUSG00000024454, ENSBTAG00000017360, ENSCAFG00845016246, ENSMMUG00000012588, ENSG00000171720
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of HDAC3 cDNA Clones/ORF Plasmid
HDAC3 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo8841 | Pre-made Human HDAC3/HD3/RPD3 siRNA oligo Duplex | 8841 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo84578 | Pre-made Rat Hdac3 siRNA oligo Duplex | 84578 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo15183 | Pre-made Mouse Hdac3 siRNA oligo Duplex | 15183 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo704467 | Pre-made Cynomolgus/Rhesus macaque HDAC3 siRNA oligo Duplex | 704467 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101100941 | Pre-made Cat/Feline HDAC3 siRNA oligo Duplex | 101100941 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo478040 | Pre-made Dog/Canine HDAC3 siRNA oligo Duplex | 478040 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo404125 | Pre-made Bovines/Cattle HDAC3 siRNA oligo Duplex | 404125 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100061405 | Pre-made Equine/Horse HDAC3 siRNA oligo Duplex | 100061405 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
HDAC3 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T05090-Ab | Human | Anti-Human HDAC3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T05090-Ab | Rat | Anti-Rat HDAC3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T05090-Ab | Mouse | Anti-Mouse HDAC3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T05090-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque HDAC3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T05090-Ab | Cat/Feline | Anti-Cat/Feline HDAC3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T05090-Ab | Dog/Canine | Anti-Dog/Canine HDAC3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T05090-Ab | Bovines/Cattle | Anti-Bovines/Cattle HDAC3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T05090-Ab | Equine/Horse | Anti-Equine/Horse HDAC3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
HDAC3 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T05090-Ag | Human | Human HDAC3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T05090-Ag | Rat | Rat HDAC3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T05090-Ag | Mouse | Mouse HDAC3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T05090-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque HDAC3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T05090-Ag | Cat/Feline | Cat/Feline HDAC3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T05090-Ag | Dog/Canine | Dog/Canine HDAC3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T05090-Ag | Bovines/Cattle | Bovines/Cattle HDAC3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T05090-Ag | Equine/Horse | Equine/Horse HDAC3 recombinant protein | Mammalian cell | Detail |