Explore ATIC gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. [provided by RefSeq, Sep 2009]
| Target ID |
GM-T04741
|
| Target Name |
ATIC
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
471
|
| Gene ID |
100054298 (Equus caballus), 101081485 (Felis catus), 108147 (Mus musculus), 471 (Homo sapiens)
488513 (Canis lupus familiaris), 506343 (Bos taurus), 694819 (Macaca mulatta), 81643 (Rattus norvegicus)
|
| Target Alternative Names |
2610509C24Rik,AICAR,AICAR transformylase/inosine monophosphate cyclohydrolase (ATIC),AICARFT,ATIC,Atic,Bifunctional purine biosynthesis protein ATIC,HEL-S-70p,IMPCHASE,PURH
|
| Uniprot Accession |
Q9CWJ9,P31939,Q0VCK0,O35567
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Metabolic pathways, Antifolate resistance
|
| Gene Ensembl |
ENSECAG00000014653, ENSMUSG00000026192, ENSG00000138363, ENSCAFG00845021597, ENSBTAG00000019274, ENSMMUG00000012318
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of ATIC cDNA Clones/ORF Plasmid
ATIC siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo471 | Pre-made Human ATIC/PURH/AICAR siRNA oligo Duplex | 471 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo81643 | Pre-made Rat Atic siRNA oligo Duplex | 81643 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo108147 | Pre-made Mouse Atic/2610509C24Rik siRNA oligo Duplex | 108147 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo694819 | Pre-made Cynomolgus/Rhesus macaque ATIC siRNA oligo Duplex | 694819 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101081485 | Pre-made Cat/Feline ATIC siRNA oligo Duplex | 101081485 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo488513 | Pre-made Dog/Canine ATIC siRNA oligo Duplex | 488513 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo506343 | Pre-made Bovines/Cattle ATIC siRNA oligo Duplex | 506343 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100054298 | Pre-made Equine/Horse ATIC siRNA oligo Duplex | 100054298 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
ATIC antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T04741-Ab | Human | Anti-Human ATIC monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T04741-Ab | Rat | Anti-Rat ATIC monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T04741-Ab | Mouse | Anti-Mouse ATIC monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T04741-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque ATIC monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T04741-Ab | Cat/Feline | Anti-Cat/Feline ATIC monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T04741-Ab | Dog/Canine | Anti-Dog/Canine ATIC monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T04741-Ab | Bovines/Cattle | Anti-Bovines/Cattle ATIC monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T04741-Ab | Equine/Horse | Anti-Equine/Horse ATIC monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
ATIC VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T04741-Ag | Human | Human ATIC VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T04741-Ag | Rat | Rat ATIC VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T04741-Ag | Mouse | Mouse ATIC VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T04741-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque ATIC VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T04741-Ag | Cat/Feline | Cat/Feline ATIC VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T04741-Ag | Dog/Canine | Dog/Canine ATIC VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T04741-Ag | Bovines/Cattle | Bovines/Cattle ATIC VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T04741-Ag | Equine/Horse | Equine/Horse ATIC VLP (virus-like particle) | HEK293 | Products Developing |
