Explore CBLB gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Introcelluar Protein.
This gene encodes an E3 ubiquitin-protein ligase which promotes proteosome-mediated protein degradation by transferring ubiquitin from an E2 ubiquitin-conjugating enzyme to a substrate. The encoded protein is involved in the regulation of immune response by limiting T-cell receptor, B-cell receptor, and high affinity immunoglobulin epsilon receptor activation. Studies in mouse suggest that this gene is involved in antifungal host defense and that its inhibition leads to increased fungal killing. Manipulation of this gene may be beneficial in implementing immunotherapies for a variety of conditions, including cancer, autoimmune diseases, allergies, and infections. [provided by RefSeq, Sep 2017]
| Target ID |
GM-T04393
|
| Target Name |
CBLB
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
868
|
| Gene ID |
100061819 (Equus caballus), 101101498 (Felis catus), 171136 (Rattus norvegicus), 208650 (Mus musculus)
487965 (Canis lupus familiaris), 525906 (Bos taurus), 703879 (Macaca mulatta), 868 (Homo sapiens)
|
| Target Alternative Names |
ADMIO3,CBLB,Casitas B-lineage lymphoma proto-oncogene b,Cbl-b,Cblb,E3 ubiquitin-protein ligase CBL-B,Nbla00127,RING finger protein 56,RING-type E3 ubiquitin transferase CBL-B,RNF56,SH3-binding protein CBL-B,Signal transduction protein CBL-B
|
| Uniprot Accession |
Q8K4S7,Q3TTA7,Q13191
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease |
cancer
|
| Disease from KEGG |
ErbB signaling pathway, C-type lectin receptor signaling pathway, T cell receptor signaling pathway, Measles
|
| Gene Ensembl |
ENSECAG00000014300, ENSMUSG00000022637, ENSCAFG00845022767, ENSBTAG00000013057, ENSMMUG00000007565, ENSG00000114423
|
| Target Classification |
Checkpoint-Immuno Oncology
|
Pre-made viral vector of CBLB cDNA Clones/ORF Plasmid
CBLB siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo868 | Pre-made Human CBLB/Cbl-b/RNF56 siRNA oligo Duplex | 868 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo171136 | Pre-made Rat Cblb siRNA oligo Duplex | 171136 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo208650 | Pre-made Mouse Cblb/Cbl-b siRNA oligo Duplex | 208650 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo703879 | Pre-made Cynomolgus/Rhesus macaque CBLB siRNA oligo Duplex | 703879 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101101498 | Pre-made Cat/Feline CBLB siRNA oligo Duplex | 101101498 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo487965 | Pre-made Dog/Canine CBLB siRNA oligo Duplex | 487965 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo525906 | Pre-made Bovines/Cattle CBLB siRNA oligo Duplex | 525906 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100061819 | Pre-made Equine/Horse CBLB siRNA oligo Duplex | 100061819 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CBLB antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T04393-Ab | Human | Anti-Human CBLB monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T04393-Ab | Rat | Anti-Rat CBLB monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T04393-Ab | Mouse | Anti-Mouse CBLB monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T04393-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CBLB monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T04393-Ab | Cat/Feline | Anti-Cat/Feline CBLB monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T04393-Ab | Dog/Canine | Anti-Dog/Canine CBLB monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T04393-Ab | Bovines/Cattle | Anti-Bovines/Cattle CBLB monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T04393-Ab | Equine/Horse | Anti-Equine/Horse CBLB monoclonal antibody | mab | Therapeutics Target antibody | Detail |
CBLB recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T04393-Ag | Human | Human CBLB recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T04393-Ag | Rat | Rat CBLB recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T04393-Ag | Mouse | Mouse CBLB recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T04393-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CBLB recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T04393-Ag | Cat/Feline | Cat/Feline CBLB recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T04393-Ag | Dog/Canine | Dog/Canine CBLB recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T04393-Ag | Bovines/Cattle | Bovines/Cattle CBLB recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T04393-Ag | Equine/Horse | Equine/Horse CBLB recombinant protein | Mammalian cell | Detail |
