Explore ADA gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine in the purine catabolic pathway. Various mutations have been described for this gene and have been linked to human diseases related to impaired immune function such as severe combined immunodeficiency disease (SCID) which is the result of a deficiency in the ADA enzyme. In ADA-deficient individuals there is a marked depletion of T, B, and NK lymphocytes, and consequently, a lack of both humoral and cellular immunity. Conversely, elevated levels of this enzyme are associated with congenital hemolytic anemia. [provided by RefSeq, Sep 2019]
| Target ID |
GM-T03661
|
| Target Name |
ADA
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
100
|
| Gene ID |
100 (Homo sapiens), 100070773 (Equus caballus), 101090683 (Felis catus), 11486 (Mus musculus)
24165 (Rattus norvegicus), 280712 (Bos taurus), 477236 (Canis lupus familiaris), 717897 (Macaca mulatta)
|
| Target Alternative Names |
ADA,ADA-like,ADA1,Ada,Adenosine aminohydrolase,Adenosine deaminase
|
| Uniprot Accession |
P00813,P03958,Q920P6,P56658
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Metabolic pathways
|
| Gene Ensembl |
ENSG00000196839, ENSECAG00000008358, ENSMUSG00000017697, ENSBTAG00000005280, ENSCAFG00845013933, ENSMMUG00000010603
|
Pre-made viral vector of ADA cDNA Clones/ORF Plasmid
ADA siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo100 | Pre-made Human ADA/ADA1 siRNA oligo Duplex | 100 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24165 | Pre-made Rat Ada siRNA oligo Duplex | 24165 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo11486 | Pre-made Mouse Ada siRNA oligo Duplex | 11486 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo717897 | Pre-made Cynomolgus/Rhesus macaque ADA siRNA oligo Duplex | 717897 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101090683 | Pre-made Cat/Feline ADA siRNA oligo Duplex | 101090683 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo477236 | Pre-made Dog/Canine ADA/ADA-like siRNA oligo Duplex | 477236 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo280712 | Pre-made Bovines/Cattle ADA siRNA oligo Duplex | 280712 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100070773 | Pre-made Equine/Horse ADA siRNA oligo Duplex | 100070773 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
ADA antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T03661-Ab | Human | Anti-Human ADA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T03661-Ab | Rat | Anti-Rat ADA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T03661-Ab | Mouse | Anti-Mouse ADA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T03661-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque ADA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T03661-Ab | Cat/Feline | Anti-Cat/Feline ADA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T03661-Ab | Dog/Canine | Anti-Dog/Canine ADA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T03661-Ab | Bovines/Cattle | Anti-Bovines/Cattle ADA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T03661-Ab | Equine/Horse | Anti-Equine/Horse ADA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
ADA VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T03661-Ag | Human | Human ADA VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T03661-Ag | Rat | Rat ADA VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T03661-Ag | Mouse | Mouse ADA VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T03661-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque ADA VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T03661-Ag | Cat/Feline | Cat/Feline ADA VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T03661-Ag | Dog/Canine | Dog/Canine ADA VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T03661-Ag | Bovines/Cattle | Bovines/Cattle ADA VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T03661-Ag | Equine/Horse | Equine/Horse ADA VLP (virus-like particle) | HEK293 | Products Developing |
