Explore IL-4RA/CD124/IL4R gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
| Target ID |
GM-T03346
|
| Target Name |
IL-4RA/CD124/IL4R
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3566
|
| Gene ID |
101096277 (Felis catus), 16190 (Mus musculus), 25084 (Rattus norvegicus), 3566 (Homo sapiens)
404154 (Bos taurus), 489957 (Canis lupus familiaris), 705404 (Macaca mulatta), 791252 (Equus caballus)
|
| Target Alternative Names |
CD124,IL-4 receptor subunit alpha,IL-4R subunit alpha,IL-4R-alpha,IL-4RA,IL4R,IL4RA,Il4r,Il4ra,Interleukin-4 receptor subunit alpha
|
| Uniprot Accession |
P16382,Q63257,P24394,Q6WG24
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target, INN Index
|
| Disease |
cancer, atopic asthma
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Hematopoietic cell lineage, Th1 and Th2 cell differentiation, Th17 cell differentiation, Pathways in cancer, Inflammatory bowel disease
|
| Gene Ensembl |
ENSMUSG00000030748, ENSG00000077238, ENSBTAG00000001602, ENSCAFG00845004286, ENSMMUG00000004666, ENSECAG00000021525
|
| Target Classification |
Cytokine Receptor, Checkpoint-Immuno Oncology
|
IL-4RA/CD124/IL4R siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3566 | Pre-made Human IL4R/CD124/IL4RA siRNA oligo Duplex | 3566 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25084 | Pre-made Rat Il4r/Il4ra siRNA oligo Duplex | 25084 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16190 | Pre-made Mouse Il4ra/Il4r/CD124 siRNA oligo Duplex | 16190 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo705404 | Pre-made Cynomolgus/Rhesus macaque IL4R siRNA oligo Duplex | 705404 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101096277 | Pre-made Cat/Feline IL4R siRNA oligo Duplex | 101096277 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo489957 | Pre-made Dog/Canine IL4R siRNA oligo Duplex | 489957 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo404154 | Pre-made Bovines/Cattle IL4R siRNA oligo Duplex | 404154 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo791252 | Pre-made Equine/Horse IL4R siRNA oligo Duplex | 791252 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
IL-4RA/CD124/IL4R antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T03346-Ab | Human | Anti-Human IL-4RA/CD124/IL4R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T03346-Ab | Rat | Anti-Rat IL-4RA/CD124/IL4R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T03346-Ab | Mouse | Anti-Mouse IL-4RA/CD124/IL4R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T03346-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque IL-4RA/CD124/IL4R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T03346-Ab | Cat/Feline | Anti-Cat/Feline IL-4RA/CD124/IL4R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T03346-Ab | Dog/Canine | Anti-Dog/Canine IL-4RA/CD124/IL4R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T03346-Ab | Bovines/Cattle | Anti-Bovines/Cattle IL-4RA/CD124/IL4R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T03346-Ab | Equine/Horse | Anti-Equine/Horse IL-4RA/CD124/IL4R monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
IL-4RA/CD124/IL4R VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T03346-Ag | Human | Human IL-4RA/CD124/IL4R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T03346-Ag | Rat | Rat IL-4RA/CD124/IL4R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T03346-Ag | Mouse | Mouse IL-4RA/CD124/IL4R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T03346-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque IL-4RA/CD124/IL4R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T03346-Ag | Cat/Feline | Cat/Feline IL-4RA/CD124/IL4R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T03346-Ag | Dog/Canine | Dog/Canine IL-4RA/CD124/IL4R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T03346-Ag | Bovines/Cattle | Bovines/Cattle IL-4RA/CD124/IL4R VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T03346-Ag | Equine/Horse | Equine/Horse IL-4RA/CD124/IL4R VLP (virus-like particle) | HEK293 | Products Developing |
