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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Transmembrane Protein.
This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
| Target ID |
GM-T03189
|
| Target Name |
PRAME
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
23532
|
| Gene ID |
101086260 (Felis catus), 102148734 (Equus caballus), 23532 (Homo sapiens), 477552 (Canis lupus familiaris)
|
| Target Alternative Names |
CT130,MAPE,Melanoma antigen preferentially expressed in tumors,OIP-4,OIP4,Opa-interacting protein 4 (OIP-4),PRAME,Preferentially expressed antigen of melanoma
|
| Uniprot Accession |
P78395
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease |
cancer
|
| Gene Ensembl |
ENSECAG00000030408, ENSG00000185686, ENSCAFG00845030057
|
| Target Classification |
Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA)
|
Pre-made viral vector of PRAME cDNA Clones/ORF Plasmid
PRAME siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo23532 | Pre-made Human PRAME/MAPE/OIP4 siRNA oligo Duplex | 23532 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101086260 | Pre-made Cat/Feline PRAME siRNA oligo Duplex | 101086260 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo477552 | Pre-made Dog/Canine PRAME siRNA oligo Duplex | 477552 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo102148734 | Pre-made Equine/Horse PRAME siRNA oligo Duplex | 102148734 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PRAME antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T03189-Ab | Human | Anti-Human PRAME monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T03189-Ab | Cat/Feline | Anti-Cat/Feline PRAME monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T03189-Ab | Dog/Canine | Anti-Dog/Canine PRAME monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T03189-Ab | Equine/Horse | Anti-Equine/Horse PRAME monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
PRAME VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T03189-Ag | Human | Human PRAME VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T03189-Ag | Cat/Feline | Cat/Feline PRAME VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T03189-Ag | Dog/Canine | Dog/Canine PRAME VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T03189-Ag | Equine/Horse | Equine/Horse PRAME VLP (virus-like particle) | HEK293 | Products Developing |
