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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Transmembrane Protein.
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T01777
|
| Target Name |
ADRA2C
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
152
|
| Gene ID |
101087990 (Felis catus), 111772982 (Equus caballus), 11553 (Mus musculus), 152 (Homo sapiens) 24175 (Rattus norvegicus), 407139 (Bos taurus), 488793 (Canis lupus familiaris), 719763 (Macaca mulatta)
|
| Target Alternative Names |
ADRA2C,ADRA2L2,ADRA2RL2,ADRARL2,ALPHA2CAR,Adra-2c,Adra2c,Alpha-2 adrenergic receptor subtype C4,Alpha-2C adrenergic receptor,Alpha-2C adrenoreceptor (Alpha-2C adrenoceptor,Alpha-2CAR),[a]2C,alpha2-C4,alpha2C
|
| Uniprot Accession |
Q01337,P18825,P22086
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction
|
| Gene Ensembl |
ENSMUSG00000045318, ENSG00000184160, ENSBTAG00000045994, ENSCAFG00845010654, ENSMMUG00000014781
|
| Target Classification |
GPCR
|
Pre-made viral vector of ADRA2C cDNA Clones/ORF Plasmid
ADRA2C siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo152 | Pre-made Human ADRA2C/ADRA2L2/ADRARL2 siRNA oligo Duplex | 152 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24175 | Pre-made Rat Adra2c siRNA oligo Duplex | 24175 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo11553 | Pre-made Mouse Adra2c/[a]2C/Adra-2c siRNA oligo Duplex | 11553 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo719763 | Pre-made Cynomolgus/Rhesus macaque ADRA2C siRNA oligo Duplex | 719763 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101087990 | Pre-made Cat/Feline ADRA2C siRNA oligo Duplex | 101087990 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo488793 | Pre-made Dog/Canine ADRA2C siRNA oligo Duplex | 488793 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo407139 | Pre-made Bovines/Cattle ADRA2C siRNA oligo Duplex | 407139 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo111772982 | Pre-made Equine/Horse ADRA2C siRNA oligo Duplex | 111772982 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
ADRA2C antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T01777-Ab | Human | Anti-Human ADRA2C monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T01777-Ab | Rat | Anti-Rat ADRA2C monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T01777-Ab | Mouse | Anti-Mouse ADRA2C monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T01777-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque ADRA2C monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T01777-Ab | Cat/Feline | Anti-Cat/Feline ADRA2C monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T01777-Ab | Dog/Canine | Anti-Dog/Canine ADRA2C monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T01777-Ab | Bovines/Cattle | Anti-Bovines/Cattle ADRA2C monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T01777-Ab | Equine/Horse | Anti-Equine/Horse ADRA2C monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
ADRA2C VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T01777-Ag | Human | Human ADRA2C VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T01777-Ag | Rat | Rat ADRA2C VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T01777-Ag | Mouse | Mouse ADRA2C VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T01777-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque ADRA2C VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T01777-Ag | Cat/Feline | Cat/Feline ADRA2C VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T01777-Ag | Dog/Canine | Dog/Canine ADRA2C VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T01777-Ag | Bovines/Cattle | Bovines/Cattle ADRA2C VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T01777-Ag | Equine/Horse | Equine/Horse ADRA2C VLP (virus-like particle) | HEK293 | Products Developing |