Explore BACE2 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
| Target ID |
GM-T01280
|
| Target Name |
BACE2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
25825
|
| Gene ID |
100058700 (Equus caballus), 101096756 (Felis catus), 25825 (Homo sapiens), 288227 (Rattus norvegicus)
478418 (Canis lupus familiaris), 534774 (Bos taurus), 56175 (Mus musculus), 715330 (Macaca mulatta)
|
| Target Alternative Names |
1110059C24Rik,AEPLC,ALP56,ARP1,ASP1,ASP21,Asp 1),Aspartic-like protease 56 kDa,Aspartyl protease 1 (ASP1,BACE2,BAE2,Bace2,Beta-secretase 2,Beta-site amyloid precursor protein cleaving enzyme 2 (Beta-site APP cleaving enzyme 2),CDA13,CEAP1,DRAP,Down region aspartic protease (DRAP),Memapsin-1,Membrane-associated aspartic protease 1,Theta-secretase
|
| Uniprot Accession |
Q9Y5Z0,Q6IE75,Q9JL18
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Alzheimer disease
|
| Gene Ensembl |
ENSECAG00000005305, ENSG00000182240, ENSCAFG00845030032, ENSBTAG00000000394, ENSMUSG00000040605, ENSMMUG00000004257
|
Pre-made viral vector of BACE2 cDNA Clones/ORF Plasmid
BACE2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo25825 | Pre-made Human BACE2/ASP1/BAE2 siRNA oligo Duplex | 25825 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo288227 | Pre-made Rat Bace2 siRNA oligo Duplex | 288227 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo56175 | Pre-made Mouse Bace2/ARP1/ASP1 siRNA oligo Duplex | 56175 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo715330 | Pre-made Cynomolgus/Rhesus macaque BACE2 siRNA oligo Duplex | 715330 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101096756 | Pre-made Cat/Feline BACE2 siRNA oligo Duplex | 101096756 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo478418 | Pre-made Dog/Canine BACE2 siRNA oligo Duplex | 478418 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo534774 | Pre-made Bovines/Cattle BACE2 siRNA oligo Duplex | 534774 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100058700 | Pre-made Equine/Horse BACE2 siRNA oligo Duplex | 100058700 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
BACE2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T01280-Ab | Human | Anti-Human BACE2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T01280-Ab | Rat | Anti-Rat BACE2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T01280-Ab | Mouse | Anti-Mouse BACE2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T01280-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque BACE2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T01280-Ab | Cat/Feline | Anti-Cat/Feline BACE2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T01280-Ab | Dog/Canine | Anti-Dog/Canine BACE2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T01280-Ab | Bovines/Cattle | Anti-Bovines/Cattle BACE2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T01280-Ab | Equine/Horse | Anti-Equine/Horse BACE2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
BACE2 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T01280-Ag | Human | Human BACE2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T01280-Ag | Rat | Rat BACE2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T01280-Ag | Mouse | Mouse BACE2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T01280-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque BACE2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T01280-Ag | Cat/Feline | Cat/Feline BACE2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T01280-Ag | Dog/Canine | Dog/Canine BACE2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T01280-Ag | Bovines/Cattle | Bovines/Cattle BACE2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T01280-Ag | Equine/Horse | Equine/Horse BACE2 VLP (virus-like particle) | HEK293 | Products Developing |
