Explore CXCR1/CD181 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T00884
|
| Target Name |
CXCR1/CD181
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3577
|
| Gene ID |
3577 (Homo sapiens), 692074 (Macaca mulatta)
|
| Target Alternative Names |
C-C,C-C-CKR-1,C-X-C chemokine receptor type 1,CD128,CD181,CDw128a,CKR-1,CMKAR1,CXC-R1,CXCR-1,CXCR1,High affinity interleukin-8 receptor A (IL-8R A),IL-8 receptor type 1,IL8R1,IL8RA,IL8RBA
|
| Uniprot Accession |
P25024,Q2YEG0
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target, Cytokine Target
|
| Disease |
cancer
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, Phospholipase D signaling pathway, Epithelial cell signaling in Helicobacter pylori infection
|
| Gene Ensembl |
ENSG00000163464, ENSMMUG00000019351
|
| Target Classification |
GPCR, Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA)
|
Pre-made viral vector of CXCR1/CD181 cDNA Clones/ORF Plasmid
CXCR1/CD181 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3577 | Pre-made Human CXCR1/C-C/CD128 siRNA oligo Duplex | 3577 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo692074 | Pre-made Cynomolgus/Rhesus macaque CXCR1/IL8RA siRNA oligo Duplex | 692074 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
CXCR1/CD181 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T00884-Ab | Human | Anti-Human CXCR1/CD181 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T00884-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CXCR1/CD181 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
CXCR1/CD181 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T00884-Ag | Human | Human CXCR1/CD181 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T00884-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CXCR1/CD181 VLP (virus-like particle) | HEK293 | Products Developing |
