Explore FPGS gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]
| Target ID |
GM-SE1505
|
| Target Name |
FPGS
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
2356
|
| Gene ID |
100070426 (Equus caballus), 100855785 (Canis lupus familiaris), 101092966 (Felis catus), 14287 (Mus musculus)
2356 (Homo sapiens), 505809 (Bos taurus), 687266 (Rattus norvegicus), 699587 (Macaca mulatta)
|
| Target Alternative Names |
FPGS,Folylpoly-gamma-glutamate synthetase (FPGS),Folylpolyglutamate synthase,Fpgs,Tetrahydrofolylpolyglutamate synthase (Tetrahydrofolate synthase),mitochondrial
|
| Uniprot Accession |
P48760,Q05932,A6H751
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Disease |
cancer
|
| Disease from KEGG |
Metabolic pathways, Antifolate resistance
|
| Gene Ensembl |
ENSECAG00000013074, ENSCAFG00845005346, ENSMUSG00000009566, ENSG00000136877, ENSBTAG00000008994, ENSMMUG00000018506
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of FPGS cDNA Clones/ORF Plasmid
FPGS siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo2356 | Pre-made Human FPGS siRNA oligo Duplex | 2356 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo687266 | Pre-made Rat Fpgs siRNA oligo Duplex | 687266 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo14287 | Pre-made Mouse Fpgs siRNA oligo Duplex | 14287 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo699587 | Pre-made Cynomolgus/Rhesus macaque FPGS siRNA oligo Duplex | 699587 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101092966 | Pre-made Cat/Feline FPGS siRNA oligo Duplex | 101092966 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100855785 | Pre-made Dog/Canine FPGS siRNA oligo Duplex | 100855785 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo505809 | Pre-made Bovines/Cattle FPGS siRNA oligo Duplex | 505809 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100070426 | Pre-made Equine/Horse FPGS siRNA oligo Duplex | 100070426 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
FPGS antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-SE1505-Ab | Human | Anti-Human FPGS monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-rg-SE1505-Ab | Rat | Anti-Rat FPGS monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-mg-SE1505-Ab | Mouse | Anti-Mouse FPGS monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cynog-SE1505-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque FPGS monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-felg-SE1505-Ab | Cat/Feline | Anti-Cat/Feline FPGS monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-cang-SE1505-Ab | Dog/Canine | Anti-Dog/Canine FPGS monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-bovg-SE1505-Ab | Bovines/Cattle | Anti-Bovines/Cattle FPGS monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
| GM-Tg-equg-SE1505-Ab | Equine/Horse | Anti-Equine/Horse FPGS monoclonal antibody | mab | FACS/Biofunctional Antibody | Detail |
FPGS recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-SE1505-Ag | Human | Human FPGS recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-SE1505-Ag | Rat | Rat FPGS recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-SE1505-Ag | Mouse | Mouse FPGS recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-SE1505-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque FPGS recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-SE1505-Ag | Cat/Feline | Cat/Feline FPGS recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-SE1505-Ag | Dog/Canine | Dog/Canine FPGS recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-SE1505-Ag | Bovines/Cattle | Bovines/Cattle FPGS recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-SE1505-Ag | Equine/Horse | Equine/Horse FPGS recombinant protein | Mammalian cell | Detail |
