Explore BMP8B gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The encoded protein stimulates thermogenesis in brown adipose tissue. Expression of this gene may be downregulated in pancreatic cancer. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1. [provided by RefSeq, Jul 2016]
| Target ID |
GM-SE0688
|
| Target Name |
BMP8B
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
656
|
| Gene ID |
100296238 (Bos taurus), 100427030 (Macaca mulatta), 102150286 (Equus caballus), 12164 (Mus musculus)
656 (Homo sapiens)
|
| Target Alternative Names |
BMP-8,BMP-8B,BMP8,BMP8B,Bmp8b,Bone morphogenetic protein 8B,OP2,Op3,Osteogenic protein 2 (OP-2)
|
| Uniprot Accession |
P55105,P34820
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Cytokine Target
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Hippo signaling pathway
|
| Gene Ensembl |
ENSBTAG00000068008, ENSMMUG00000058881, ENSMUSG00000002384, ENSG00000116985
|
Pre-made viral vector of BMP8B cDNA Clones/ORF Plasmid
BMP8B siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo656 | Pre-made Human BMP8B/OP2/BMP8 siRNA oligo Duplex | 656 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12164 | Pre-made Mouse Bmp8b/Op3 siRNA oligo Duplex | 12164 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100427030 | Pre-made Cynomolgus/Rhesus macaque BMP8B siRNA oligo Duplex | 100427030 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100296238 | Pre-made Bovines/Cattle BMP8B siRNA oligo Duplex | 100296238 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo102150286 | Pre-made Equine/Horse BMP8B siRNA oligo Duplex | 102150286 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
BMP8B antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-SE0688-Ab | Human | Anti-Human BMP8B monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
| GM-Tg-mg-SE0688-Ab | Mouse | Anti-Mouse BMP8B monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-SE0688-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque BMP8B monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-SE0688-Ab | Bovines/Cattle | Anti-Bovines/Cattle BMP8B monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
| GM-Tg-equg-SE0688-Ab | Equine/Horse | Anti-Equine/Horse BMP8B monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
BMP8B recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-SE0688-Ag | Human | Human BMP8B recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-SE0688-Ag | Mouse | Mouse BMP8B recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-SE0688-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque BMP8B recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-SE0688-Ag | Bovines/Cattle | Bovines/Cattle BMP8B recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-SE0688-Ag | Equine/Horse | Equine/Horse BMP8B recombinant protein | Mammalian cell | Detail |
