Explore A2ML1 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a member of the alpha-macroglobulin superfamily. The encoded protein is thought to be an N-glycosylated monomeric protein that acts as an inhibitor of several proteases. It has been shown to form covalent interactions with proteases, and has been reported as the p170 antigen recognized by autoantibodies in the autoimmune disease paraneoplastic pemphigus (PNP; PMID:20805888). Mutations in these gene have also been associated with some cases of Noonan syndrome (NS; PMID:24939586) as well as some cases of otitis media (PMID:26121085). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
| Target ID |
GM-SE0631
|
| Target Name |
A2ML1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
144568
|
| Gene ID |
100061421 (Equus caballus), 101101643 (Felis catus), 144568 (Homo sapiens), 486697 (Canis lupus familiaris)
516769 (Bos taurus), 716616 (Macaca mulatta)
|
| Target Alternative Names |
A2ML1,Alpha-2-macroglobulin-like protein 1,C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9,CPAMD9,OMS,p170
|
| Uniprot Accession |
A8K2U0
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Cytokine Target
|
| Disease |
Perinatal necrotizing enterocolitis
|
| Gene Ensembl |
ENSECAG00000024232, ENSG00000166535, ENSCAFG00845029001, ENSBTAG00000004097, ENSMMUG00000022680
|
A2ML1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo144568 | Pre-made Human A2ML1/OMS/p170 siRNA oligo Duplex | 144568 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo716616 | Pre-made Cynomolgus/Rhesus macaque A2ML1 siRNA oligo Duplex | 716616 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101101643 | Pre-made Cat/Feline A2ML1 siRNA oligo Duplex | 101101643 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo486697 | Pre-made Dog/Canine A2ML1 siRNA oligo Duplex | 486697 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo516769 | Pre-made Bovines/Cattle A2ML1 siRNA oligo Duplex | 516769 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100061421 | Pre-made Equine/Horse A2ML1 siRNA oligo Duplex | 100061421 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
A2ML1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-SE0631-Ab | Human | Anti-Human A2ML1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-SE0631-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque A2ML1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
| GM-Tg-felg-SE0631-Ab | Cat/Feline | Anti-Cat/Feline A2ML1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
| GM-Tg-cang-SE0631-Ab | Dog/Canine | Anti-Dog/Canine A2ML1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-SE0631-Ab | Bovines/Cattle | Anti-Bovines/Cattle A2ML1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
| GM-Tg-equg-SE0631-Ab | Equine/Horse | Anti-Equine/Horse A2ML1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
A2ML1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-SE0631-Ag | Human | Human A2ML1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-SE0631-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque A2ML1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-SE0631-Ag | Cat/Feline | Cat/Feline A2ML1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-SE0631-Ag | Dog/Canine | Dog/Canine A2ML1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-SE0631-Ag | Bovines/Cattle | Bovines/Cattle A2ML1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-SE0631-Ag | Equine/Horse | Equine/Horse A2ML1 recombinant protein | Mammalian cell | Detail |
